Differential expression of Toll-like receptors in follicular lymphoma,diffuse large B-cell lymphoma and peripheral T-cell lymphoma |
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| Authors: | Thomas J Smith Kouhei Yamamoto Morito Kurata Akane Yukimori Shiho Suzuki Shigeaki Umeda Emiko Sugawara Yousuke Kojima Motoji Sawabe Yasunori Nakagawa Kenshi Suzuki James TB Crawley Masanobu Kitagawa |
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| Institution: | 1. Department of Comprehensive Pathology, Ageing and Developmental Sciences, Graduate School, Tokyo Medical and Dental University, 1-5-45 Bunkyo-ku, Tokyo, Japan;2. Department of Haematology, Imperial College London, London, UK;3. Department of Pathology, Tokyo Metropolitan Geriatric Hospital, Tokyo, Japan;4. Department of Hematology, Japanese Red Cross Medical Center, Tokyo, Japan;1. Department of Surgery, Minamisoma Municipal General Hospital, Minamisoma, Fukushima, Japan;2. Department of Epidemiology and Biostatistics, Graduate School of Public Health, Teikyo University, Tokyo, Japan;3. Department of Internal Medicine, Soma Central Hospital, Soma, Fukushima, Japan;1. Department of Molecular Medicine, Faculty of Advanced Medical Technologies, Golestan University of Medical Sciences, Golestan, Iran;2. Department of Cell and Molecular Biology, Faculty of Science, Razi University, Kermanshah, Iran;3. Center for Biotechnology, Institute of Science and Technology, Jawaharlal Nehru Technological University, Hyderabad, India;1. Organ Transplantation Institute, Xiamen University, Fujian Province 361000, PR China;2. Division of Gastroenterology Surgery, Zhongshan Hospital, Gastroenterology Institute of Xiamen University, Gastroenterology Center of Xiamen, Fujian Province 361000, PR China;3. Basic Medical Department of Medical College, Xiamen University, Fujian Province 361000, PR China |
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| Abstract: | Although Toll-like receptors (TLRs) in mammals are well-known to play important roles in innate immunity, newer roles for the TLRs have suggested that cells with aberrant TLR expression may have a survival advantage over normal cells. Lymphocytes are one of a small number of cell types that express many of the TLRs, suggesting that abnormal TLR levels/signaling may potentially influence the progression of malignant lymphomas. Thus, frozen samples of 51 lymph nodes from patients with follicular lymphoma (FL), diffuse large B-cell lymphoma (DLBCL) and peripheral T-cell lymphoma (PTCL) were analyzed for the expression of TLR1 to 9 using quantitative real-time PCR, and compared to those in reactive lymphadenopathy (RL) samples. TLR2 was over-expressed in both DLBCL and PTCL but not in FL when compared to RL. TLR1 and TLR4 expression was up-regulated in PTCL, while TLR8 was highly expressed in DLBCL. Although TLR5 showed lower expression in FL, expression of TLR3, TLR6, TLR7 and TLR9 did not vary significantly between different lymphoma subtypes. Double immunostaining revealed an increase in the number of TLR2 and/or TLR8 expressing lymphoma cells in DLBCL. In PTCL, TLR2 and TLR4 expression was localized to neoplastic T cells. TLR expression is highly variable among lymphoma subtypes. However, despite this some significant differences exist that may prove useful in the development of novel therapeutic strategies. |
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