Reference values for serum nitric oxide metabolites in an adult population |
| |
| Authors: | Asghar Ghasemi Saleh Zahediasl Fereidoun Azizi |
| |
| Affiliation: | 1. Department of Biomedical Sciences, School of Medicine, University of Sassari, Sassari, Italy;2. Department of Veterinary Medicine, University of Sassari, Sassari, Italy;3. AGRIS Sardegna, Loc. Bonassai, Sassari, Italy;4. Discipline of Clinical Pharmacology, College of Medicine and Public Health, Flinders University and Flinders Medical Centre, Adelaide, Australia;1. Institute of Clinical Pharmacology, Hannover Medical School, Hannover, Germany;2. Department of Cardiology, The Queen Elizabeth Hospital, The University of Adelaide, Adelaide, Australia |
| |
| Abstract: | ObjectivesTo determine reference values for serum nitric oxide metabolites (nitrite + nitrate = NOx) concentrations in adult subjects.Design and methodsSerum NOx concentration was measured, using the Griess method, in 694 non-smoking apparently healthy subjects, randomly selected from a population-based study. The International Federation of Clinical Chemistry guidelines and the robust method were used for determining reference values.ResultsThe 95% reference values for serum NOx concentration and serum NOx/creatinine ratio were 11.5 to 76.4 μmol/L and 0.111 to 0.729 in men and 10.1 to 65.6 μmol/L and 0.121 to 0.777 in women, respectively. With increasing body mass index, upper limits of serum NOx and the NOx/creatinine ratio increased in women and decreased in men. Serum NOx levels above upper limits predicted both diabetes and metabolic syndrome in women.ConclusionsThis study reports the first set of reference values for serum NOx concentration and NOx/creatinine ratio in a relatively large healthy non-smoking population. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
