In vivo notch reactivation in differentiating cochlear hair cells induces sox2 and prox1 expression but does not disrupt hair cell maturation |
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| Authors: | Zhiyong Liu Thomas Owen Jie Fang R. Sathish Srinivasan Jian Zuo |
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| Affiliation: | 1. Department of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, Tennessee;2. Integrated Program in Biomedical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee;3. University of Bath, Bath, United Kingdom;4. Department of Genetics and Tumor Cell Biology, St. Jude Children's Research Hospital, Memphis, Tennessee |
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| Abstract: | COVER PHOTOGRAPH: Lineage tracing of Prox1 expressing inner ear cochlear cells in Prox1CreEGFP/+; Rosa26‐EYFPloxp/+ mice at P23. All cochlear hair cells are labeled with calbindin in red. EYFP in green historically records the cochlear cells experiencing Prox1 expression during the development, which include hair cells and supporting cells (both inside and outside the organ of Corti). From Liu et al., Developmental Dynamics 241:684–696, 2012. |
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| Keywords: | Notch cochlea hair cells Sox2 Prox1 differentiation |
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