Comparison of dynamic contrast‐enhanced MRI and quantitative SPECT in a rat glioma model |
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| Authors: | Jack T. Skinner Thomas E. Yankeelov Todd E. Peterson Mark D. Does |
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| Affiliation: | 1. Department of Biomedical Engineering, Vanderbilt University, , Nashville, TN, 37232‐2310 USA;2. Vanderbilt University Institute of Imaging Science, Vanderbilt University, , Nashville, TN, 37232‐2310 USA;3. Department of Radiology and Radiological Sciences, Vanderbilt University School of Medicine, , Nashville, TN, 37232‐2310 USA;4. Department of Physics, Vanderbilt University, , Nashville, TN, 37232‐2310 USA;5. Department of Cancer Biology, Vanderbilt University, Department of Electrical Engineering, Vanderbilt University, , Nashville, TN, 37232‐2310 USA |
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| Abstract: | ![]()
Pharmacokinetic modeling of dynamic contrast‐enhanced (DCE) MRI data provides measures of the extracellular‐extravascular volume fraction (ve) and the volume transfer constant (Ktrans) in a given tissue. These parameter estimates may be biased, however, by confounding issues such as contrast agent and tissue water dynamics, or assumptions of vascularization and perfusion made by the commonly used model. In contrast to MRI, radiotracer imaging with SPECT is insensitive to water dynamics. A quantitative dual‐isotope SPECT technique was developed to obtain an estimate of ve in a rat glioma model for comparison with the corresponding estimates obtained using DCE‐MRI with a vascular input function and reference region model. Both DCE‐MRI methods produced consistently larger estimates of ve in comparison to the SPECT estimates, and several experimental sources were postulated to contribute to these differences. Copyright © 2012 John Wiley & Sons, Ltd. |
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| Keywords: | MRI dynamic contrast DCE tumor pharmacokinetic modeling SPECT radionuclide diffusion |
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