乳腺纤维囊性病性激素周期节律的变化

测定133例乳腺纤维囊性病(FCD)和17例正常人卵泡期、排卵期、黄体期、月经前期血和尿雌二醇(E_2)和孕酮(P)。根据性激素分泌类型不同分为5型:A型54例,E_2和P分泌峰提前出现,P分泌时相延长,E_2在排卵期分泌显著降低;B型16例,P分泌正常。但排卵期E_2浓变显著降低;C型16例,排卯期E_2分泌降低,黄体期出现P分泌峰,但其分泌延迟至月经前期,同时伴有E_2浓度增加;D型41例,虽然排卵期E_2和黄体期P分泌正常,但E_2和P分泌延迟消失,在月经前期均未能回复到正常;E型6例,没有P分泌,血尿E_2含量在月经周期中均处于低水平。对各型FCD患者与正常人血、尿E_2平均数进行比较,表明FCD的共同特点是卵泡期和月经前期血清E_2浓度增加和排卵期E_2浓度降低。

ANALYSIS OF ESTROGEN AND PROGESTERONE LEVELS DURING MENSTRUAL CY-CLE IN PATIENTS WITH FIBROCYSTIC DISEASE OF BREAST

The blood and urine estrogen (E2) and progesterone (P) were measured in 133 patients with fibrocystic disease (FCD) of breast and 17 healthy subsjects during menstrual cycle phases. According to the characteristics of the secretion, the patients were divided into five types. Type A (54 patients): The secretion peak of E2 and P appeared beforehand and secretion of P was prolonged and E2 decreased significantly in ovulatory phase. Type B (16 patients): The secretion peak of E2 disappeared in ovulatory phase although the secretion of P was normal. Type C (16 patients): The secretion peak of P deferred its disappearance and maintained at higher level till pre-menstrual period and sc did E2: the secretion of E2 decreased in ovulatory phase. Type D (41 patients): The secretion peak of E2 in ovulatory phase was normal but could not return to normal level in pre-menstrual period, in the mean time the secretion of P also deferred its disappearance. Type E (6 patients): There was no secretion of P and the blood and urine concentrations of E2 deccreased in all phases. The average value of E2 in the patients with FCD was compared with that of healthy subjects. The concentration of E2 in all the patients increased in follicular and pre-menstrual phases. However, the concentration of E2 in ovulatory phase was much lower in the patients than in healthy subjects.