卵巢癌~(99m)Tc-MIBI显像与化疗疗效的相关性

目的 探讨卵巢癌~(99m)Tc-MIBI显像与化疗疗效的关系及临床意义.方法 对28例卵巢癌复发患者进行~(99m)Tc-MIBI显像,采集10 min及60 min两时相的平面像,采用感兴趣区(ROI)技术计算早期和延迟相肿瘤/非肿瘤(T/N)比值及滞留指数(RI);采用TP方案进行化疗,并与T/N、滞留指数进行相关性分析.结果 T/N比值及滞留指数低者,对化疗不敏感;T/N比值高、滞留指数高者,化疗有效,差异有统计学意义.结论 ~(99m)Tc-MIBI亲肿瘤显像能预测卵巢癌化疗敏感性,为临床个体化治疗提供理论依据.

Correlation Between ~(99m)Tc-MIBI Scintigraphy of Ovarian Cancer and Efficacy of Chemotherapy

Objective To evaluate the relationship between the ~(99m)Tc-MIBI Scintigraphy of ovarian cancer and the efficacy of chemotherapy. Methods Twenty-eight patients with advanced ovarian cancer underwent WmTc-MIBI cintigraphy. Static planar images were taken at 10 min and 60 min after scintigraphy. Meanwhile technique of region-of-interest (ROI) was used to calculate T/ N and retention indices of ~(99M)Tc -MIBL Each patient received chemotherapy of TP. Results The patients with low T/N and low retention indices had poor efficacy of chemotherapy. The patients with high T/N and high retention have good efficacy of chemotherapy. There was significant difference between two groups. Conclusion The ~(99m)Tc-MIBI Scintigraphy may be used to evaluate the efficacy of chemotherapy in ovarian cancer, and thus can offer theoretical basis for individual therapy.