钛基植入物材料纳米涂层修饰促骨整合性能研究进展

钛基金属材料具有优越的力学性能，弹性模量低，抗腐蚀性强，生物相容性好，是目前骨科常用的内固定材料。但是，钛基金属自身的生物惰性对其作为骨植入物的骨整合性能有一定影响。通过对钛基金属表面涂层修饰来提高骨整合性能是目前骨植入物材料研究领域的热点。无机钙磷酸盐材料以及有机生物分子（包括细胞外基质成分，生长因子以及酶分子等）获得了广泛的研究，有机－无机复合物涂层显示出良好的应用前景，有望作为新的涂层材料来提高钛基金属材料的骨整合性能以及生物效能。

Surface coating for titanium based implant to enhance osseointegration

Titanium and its alloys are widely used for orthopedic implants for their superior mechanical peoperties,low modulus,excellent corrosion resistance and good biocompatibility.however,titanium,being bioinert,cannot directly bond to bone,reduce their osseointegration property.hence ,there is a growing interest in generate a coating onto a titanium surface to promote fixation of bone/titanium-based implants.various techniques are used to this end by either inorganic (calcium phosphate) or organic(extracellular matrix components,growth factors,enzymes,etc) components of natural bone tissue.the combinationg,however,of both organic constituents is expected to result into truly bone-resembling coating,and as such to a new generation of surface-coated titanium implants with improved osseointegration and biological efficacy.