替罗非班对急性冠脉综合征患者急诊介入治疗效果的影响

目的: 观察国产替罗非班对急性冠脉综合征(acute coronary syndrome, ACS)急诊介入治疗效果的影响。方法： 入选住院ACS患者210例，随机分为替罗非班组(102例)和对照组(108例)，比较两组基础临床资料、介入治疗情况、住院期间主要不良心脏事件发生率、出血并发症和心律失常相关事件的发生率。结果： 两组患者基本临床资料和介入治疗情况、出血并发症间的差异均无统计学意义(P>0.05)。与对照组比较，替罗非班组患者住院期间主要不良心脏事件和缓慢型心律失常发生率明显减少，早期β受体阻滞剂使用率提高，室性心律失常电击复律/除颤率也有所降低。结论： 替罗非班提高了ACS患者急诊介入治疗的效果，可明显降低急诊介入治疗围术期心律失常的发生率。

Effects of tirofiban treatment on emergency percutaneous coronary intervention in patient with acute coronary syndrome

Objective: To observe the effects of tirofiban treatment in emergency percutaneous coronary intervention(PCI) of acute coronary syndrome(ACS) patients.  Methods: A total of 210 hospitalized patients with ACS were selected, randomly divided into tirofiban group(108) and control group(102). Clinical data, interventional treatment, major adverse cardiac events during hospitalization, incidence of arrhythmia, bleeding complications and related events of two groups were compared. Results:The differences of clinical information, interventional treatment and bleeding complications with the two groups of patients were not statistically significant(P>0.05).Compared with the control group, the incidence of major adverse cardiac events of tirofiban group was significantly reduced during hospitalization. The incidence of bradycardia of tirofiban group was significantly lower than that of control group. Earlier treatment with  beta blockade in our study was one of the outcomes  facilitated by tirofiban treatment. The patients put on tirofiban also experienced less ventricular arrhythmia mandating electric cardioversion/defibrillation. Conclusion: Tirofiban improved the effects of emergency interventional therapy and reduced arrhythmia during operation period in acute coronary syndrome patients.  ［Key words］tirofiban; acute coronary syndrome; percutaneous coronary intervention； arrhythmia