心肌肌钙蛋白Ⅰ快速检测在急性心肌梗死诊断中的价值

比较心肌肌钙蛋白Ⅰ(CTnI)与几种常用的急性心肌梗死(AMI)诊断标记物的临床应用价值。方法对36例AMI和70 例非心肌梗死患者同时检测血清CTnI、肌酸激酶(CK)、肌酸激酶同功酶(CK-MB)、乳酸脱氢酶(LDH)、天冬氨酸转氨酶(AST)和α-羟丁 酸脱氢酶(α-HBD)等6项指标，并进行2组间比较，分别对AMI和非心肌梗死组各指标间的差异作对比分析。结果CTnI诊断AMI的敏 感性(91.7％)高于CK(75.0％)、CK-MB(63.9％)、AST(66.3％)、LDH(75.0％)、α-HBD(69.4％)，P<0.05～0.01；CTnI诊断AMI的特异 性(95.7％)与CK-MB(92.6％)相近(P>0.05)，高于CK(84.3％)、ASr(81.4％)、LDH(72.9％)及α-HBD(80.0％)，P<0.05～0.01。结论 CTnI对AMI的诊断具有较高的敏感性和特异性，作为一种心肌损伤的特异标记物，具有较好的临床应用价值。

Diagnosis value of rapid cardiac troponin

Objective To compare the clinical diagnosis value of cardiac troponin Ⅰ (CTnI) and creatine kinase (CK), cre atine kinase MB (CK-MB), aspartic transaminase (AST), lactic dehydrogenase (LDH) and α- hydroxybutyric dehydrogenase (α- HBD) in patients with acute mycoardial infarction (AMI) . Methods The serum level of CTnI, CK, CK - MB, AST, LDH and α - HBD were simultaneously measured in 36 patients with AMI and 70 patients without myocardial infarction. Results The sensitivity of CTnI for diagnosis of AMI was 91.7% which was significantly higher than that of CK, CK - MB, AST, LDH and α - HBD (75%, 63.9%, 66.7%, 75%, 69.4% respectively, p < 0.05 ～ 0.01). Moreover, the specificity of CTnI was 95.7%, which was similar to CK - MB (92.6%, p > 0.05), while remarkably higher than CK, AST, LDH and α - HBD (84.3 %, 81.4%, 72.9%, 80% re spectively, p < 0. 05 ～ 0. 001 ). Conclusion CTnI was a useful marker for cardiac damage, which had high sensitivity, specificity and value of clinical used for diagnosis of AMI.