三阴性乳腺癌的临床病理特点及预后因素分析

目的探讨三阴性（TN）乳腺癌的临床病理特点及影响预后的因素。方法回顾性分析515例乳腺癌患者，根据雌激素受体（ER）、孕激素受体（PR）和人表皮生长因子受体2（HER2）的表达，将其分为3组：三阴组（ER阴性、PR阴性、HER2阴性）、HR组（ER阳性或PR阳性、HER2阴性或阳性）、HER2组（ER阴性、PR阴性、HER2阳性）。分析各组的临床病理特点、复发及生存情况。结果三阴组与HR组、HER2组相比．患者年龄小、肿瘤较大、浸润性导管癌多见，淋巴结转移率与肿瘤大小有统计学意义；三阴组复发时间较早（2．32年），复发率（23．91％）和死亡率（22．72％）均较高；患者复发风险呈先升后降的趋势：术后1～4年达到顶峰，之后下降。结论三阴性乳腺癌患者诊断时年龄小、原发肿瘤大、淋巴结转移率高、术后5年内复发和死亡风险高。

The Clinicopathologic Characteristics and Prognostic Factors Analysis of the ER,PR,HER2 Negative Breast Cancer

Objective To analyze the clinicopathological characteristics and prognostic factors in ER,PR,HER-2 negative breast cancer. Methods The data of 515 were retrospectively analyzed. According to the expression of ER,PR,HER2, 515 patients were put into 3 groups. HR （ER or PR＋） ,triple negative （all ER, PR, HER2 ＋ ）, and HER2 （ER -, PR-, HER2 ＋ ）. The clinicopathological features, recurrence and survival of each group were analyzed. Results The mean age for the triple negative group was （48.53±9.09） ; The mean tumor size was （3.52 ± 1.36）cm. Invasive ductal carcinoma in this group were the highest proportion; and the lymph node metastasis rate and tumor size were statistically significant. The triple negative group relapsed earlier （2. 32 years）, relapse rate （23. 91%） and mortality （22.72%） are higher; The trend of relapse risk about the triple negative group was first and then decreased： Peaked within 1～3 years, followed by decline. Conclusion Compared with non TN, the breast cancer patiens with triple-negativeis characterized by the following： younger,larger primary tumor, higher rate of lymphnode metastasis, the higher risk of recurrence and death within 5 years.