钼靶联合hMAM、BRCA-1表达水平检测对乳腺癌的诊断价值

目的探讨钼靶联合乳腺癌人乳腺珠蛋白(hMAM)基因、乳腺癌易感基因-1(BRCA-1)表达水平对乳腺癌的诊断价值。方法选取2016年1月至2019年8月在该院就诊的乳腺癌患者150例纳入肿瘤组,另选取同期良性乳腺肿瘤患者100例纳入良性组。通过受试者工作特征(ROC)曲线分析单独及联合应用钼靶及hMAM、BRCA-1检测诊断乳腺癌的灵敏度、特异度、ROC曲线下面积(AUC)等。结果肿瘤组钼靶检测阳性率(68.7%)明显高于良性组(27.0%),差异有统计学意义(χ2=41.730,P<0.05)。肿瘤组hMAM表达水平明显高于良性组,BRCA-1表达水平明显低于良性组,差异有统计学意义(t=49.723、30.632,P<0.05)。钼靶及hMAM、BRCA-1联合检测诊断乳腺癌的灵敏度(78.7%)明显高于单独检测的灵敏度(68.7%、57.3%、60.7%),差异有统计学意义(P<0.05),还保持了较高的特异度(79.0%),联合检测的AUC(0.864)明显高于单独检测(0.792、0.753、0.642),差异有统计学意义(P<0.05)。结论钼靶检测及hMAM、BRCA-1表达水平检测可提高乳腺癌诊断的灵敏度,并保持较高的特异度,对乳腺癌诊断有重要的临床价值。

Diagnostic value of molybdenum target combined with the expression level of human breast cancer mammaglobin gene and breast cancer susceptibility gene-1 in breast cancer patients

Objective To analyze diagnostic value of molybdenum target combined with the expression level of human breast cancer mammaglobin gene(hMAM)and breast cancer susceptibility gene-1(BRCA-1)in breast cancer patients.Methods A total of 150 patients with breast cancer from January 2016 to August 2019 were selected as tumor group,and 100 benign breast cancer patients in the same period were selected as benign group.The sensitivity,specificity,and area under the receiver operating characteristic(ROC)curve(AUC)of single indicator detection and combination with hMAM,BRCA-1 expression levels and molybdenum target in the diagnosis of breast cancer were analyzed by ROC curve.Results The positive rate of molybdenum target test in tumor group(68.7%)was significant higher than that in benign group(27.0%,χ2=41.730,P<0.05).The expression level of hMAM in tumor group was significantly higher than that in benign group(t=49.723,P<0.05).The expression level of BRCA-1 in tumor group was significantly lower than that in benign group(t=30.632,P<0.05).The sensitivity(78.7%)of the combined diagnosis for breast cancer was significantly higher than that of single detection(68.7%,57.3%,60.7%,P<0.05),and maintained a high specificity(79.0%).The AUC of the combined detection(0.864)was significantly higher than those of single indicator(0.792,0.753,0.642,P<0.05).Conclusion The combined detection of molybdenum target and the expression level of hMAM and BRCA-1 could improve the sensitivity of breast cancer diagnosis and maintain high specificity,which has important clinical value for breast cancer diagnosis.