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| 神经肽Y在急性肾缺血再灌注损伤中的变化 | |
| 引用本文： | 李爱芝. 神经肽Y在急性肾缺血再灌注损伤中的变化[J]. 临床和实验医学杂志, 2010, 3(3): 165-166 |
| 作者姓名： | 李爱芝 |
| 作者单位： | 烟台毓璜顶医院麻醉科,山东,烟台,264000 |
| 基金项目： | 烟台市科技发展计划项目 |
| 摘 要： | 目的探讨血浆神经肽Y（NPY）在急性肾缺血再灌注损伤时的变化规律。方法SD大鼠32只,随机分为对照组和缺血再灌注组,每组16只。建立大鼠急性肾缺血再灌注损伤模型,缺血再灌注后3h分别检测血浆NPY,血清尿素氮（BUN）、肌酐（Cr）、超氧化物歧化酶（SOD）、丙二醛（MDA）及观察肾组织的病理学变化。结果与对照组比较,缺血再灌注组血浆NPY,血清BUN、Cr、MDA水平显著升高（P〈0.05）,SOD水平显著降低（P〈0.05）;与对照组比较,缺血再灌注组肾组织病理损伤程度明显加重。结论大鼠急性肾缺血再灌注损伤血浆NPY水平与肾脏受损程度呈正相关,NPY可作为在急性肾缺血再灌注损伤中估计肾脏受损程度的主要检测指标之一。 |
| 关 键 词： | 神经肽Y 缺血再灌注损伤 肾脏 |
Plasma neuropeptide Y concentration changes in rats with acute renal ischemia-reperfusion injury |
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| LI Ai-zhi. Plasma neuropeptide Y concentration changes in rats with acute renal ischemia-reperfusion injury[J]. Journal of Clinical and Experimental Medicine, 2010, 3(3): 165-166 | |
| Authors: | LI Ai-zhi |
| Affiliation: | LI Ai-zhi. Department of Anesthesiology,Yantai Yuhuangding Hospital,Yantai Sh,ong,264000,China. |
| Abstract: | Objective To explore the plasma neuropeptide Y (NPY) concentration changes in rats with acute renal ischemia-reperfusion injury.Methods Thirty-two Sprague-Dawley rats were randomly divided into a control group and an ischemia-reperfusion group with 16 rats in each group. We established the acute renal ischemia-reperfusion injury model in rats. NPY concentration,blood urea nitrogen (BUN),creatinine (Cr),serum superoxide dismutase (SOD) and malondialdehyde (MDA) were assessed after 3 hours of renal ischemia-r... |
| Keywords: | Neuropeptide Y Ischemia-reperfusion injury Kidney |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |