胰岛素样生长因子结合蛋白3在疾病诊断与风险评估中的潜在价值

背景：胰岛素样生长因子1在细胞的生长、增殖与分化等方面发挥了重要作用,而IGFBP-3作为胰岛素样生长因子1的主要结合蛋白,参与了对胰岛素样生长因子1生理功能的调控。目的：试图分析胰岛素样生长因子结合蛋白3与多种疾病的关系,探索胰岛素样生长因子结合蛋白3在这些疾病诊断与风险评估中的潜在应用价值。方法：以＂insulin-like growth factors 1;IGFBP-3;cancer;growth hormone deficiency;diabetes;osteoporosis＂为检索词检索PubMed数据库、英文数据库及万方医学网。收集与胰岛素样生长因子结合蛋白3结构及功能相关的文献,以及胰岛素样生长因子结合蛋白3与癌症、生长激素缺乏症、糖尿病及骨质疏松相关的文献,最后选择43篇进行归纳总结。结果与结论：近年来,胰岛素样生长因子结合蛋白3的基因与癌症风险的相关性研究正逐渐成为一个研究热点。结果表明,胰岛素样生长因子结合蛋白3是一种癌症风险的保护剂,是评估癌症风险的重要因子,具有潜在的应用价值。胰岛素样生长因子结合蛋白3还与生长激素缺乏症、糖尿病相关,并可与胰岛素样生长因子1协同作用对骨的生长分化发挥调控作用,与骨质疏松有着紧密的联系,可作为一种预测骨质疏松的潜在指标。

The potential values of insulin-like growth factor binding protein 3 in disease diagnosis and risk assessment

BACKGROUND： Insulin-like growth factor 1 （IGF1） plays an important role in cell growth, proliferation and differentiation. Insulin-like growth factor binding protein 3 （IGFBP-3）, as the main binding protein of IGF1, is involved in the regulation of IGFI. OBJECTIVE： To attempt to analyze the relation of IGFBP-3 and various diseases, and to explore the potential values of IGFBP-3 in disease diagnosis and risk assessment. METHODS： Databases of PubMed, Science Direct and Wanfang database were retrieved with key words of ＂insulin-like growth factors 1; IGFBP-3; cancer; growth hormone deficiency; diabetes; osteoporosis＂ in English and Chinese, respectively, by screening titles and abstracts to search papers related to IGFBP-3 structure and function as well as relationship of IGFBP-3 with cancer, growth hormone deficiency, diabetes, osteoporosis. Finally, 43articles were summarized according to inclusion criteria. RESULTS AND CONCLUSION： In recent years, the relationship between gene of IGFBP-3 and risk of cancer is becoming a hot research topic. The results show that IGFBP-3 is a protective agent of cancer risk,-and it is an important factor in evaluating the risk of cancer, exhibiting a potential application value. IGFBP-3 is also associated with growth hormone deficiency and diabetes. In addition, IGFBP-3 can assist IGF-1 to play the regulatory role in bone growth and differentiation, which is closely linked with osteoporosis. Therefore, IGFBP-3 carl be a potential predictor for osteoporosis.