中药诱导骨髓间充质干细胞的成骨分化

背景：近年来研究显示,中药在诱导骨髓间充质干细胞向成骨方向分化起到积极作用。目的：综述中药诱导骨髓间充质干细胞分化为成骨细胞的研究进展。方法：以＂中药,骨髓间充质干细胞,成骨细胞＂为检索词,检索万方医学数据库中2004年1月至2012年4月的文献,纳入中药诱导骨髓间充质干细胞分化为成骨细胞的相关研究,最终入选18篇文章进行总结分析。结果与结论：中药血清药理学认为中药血清既能去除中药内未知的毒性又能反映中药的药效,在上述理论的指导下,许多学者将含补肾、接骨等中药血清应用于诱导骨髓间充质干细胞向成骨细胞分化的研究。结果显示,这些单味中药、单味药提取物、复方药含药血清均可以促进体外培养的骨髓间充质干细胞诱导分化为成骨细胞,具有安全、使用简便等特点。

Chinese medicines induce bone marrow mesenchymal stem cells differentiating into osteoblasts

BACKGROUND： Recent studies have shown that Chinese medicines appear to have an active inducible role in the osteogenic differentiation of bone marrow mesenchymal stem cells. OBJECTIVE： To review the progress of Chinese medicine in the induced differentiation of bone marrow mesenchymal stem cells into osteoblasts. METHODS： A computer-based search of Wanfang database was performed to retrieve articles addressing Chinese medicine for inducing osteogenic differentiation of bone marrow mesenchymal stem cells, published from January 2004 to April 2012. The key words were ＂Chinese medicine, bone marrow mesenchymal stem cells osteoblasts＂ in Chinese. Finally, 18 articles were included in result analysis. RESULTS AND CONCLUSION： Based on serum pharmacology, serum containing Chinese medicine cannot only remove unknown toxicity, but also reflect the efficacy of Chinese medicine. Therefore, serums containing drugs for tonifying the kidney and bone knitting have been used to induce differentiation of bone marrow mesenchymal stem cells into osteoblasts. These serums containing single herbs, single herb extracts, and drug compounds are characterized as safe and easy to use, which can all promote in vitro differentiation of bone marrow mesenchymal stem cells into osteoblasts.