运动应激状态下的心肌热休克蛋白表达

背景：热休克蛋白因其具有特殊的生物学特性,在运动应激下探讨此类蛋白质在心肌的表达情况具有重要的研究价值。目的：了解国内外有关运动应激状态下心肌热休克蛋白表达的研究情况,对不同运动应激下心肌热休克蛋白的表达特点及意义进行分析。方法：以＂heat shock protein;myocardium;exercise stress＂为英文检索词;以＂热休克蛋白;心肌;运动应激＂为中文检索词,检索1991年1月至2014年1月检索PubMed数据库及万方数据库与热休克蛋白的产生、分类及功能有关、与运动应激下心肌热休克蛋白的表达相关、与运动应激下心肌热休克蛋白表达的机制相关及运动应激下心肌热休克蛋白表达的意义相关的文献。最终选择48篇进行归纳总结。结果与结论：热休克蛋白具有免疫协同作用。研究报道,运动训练能引起心肌热休克蛋白的表达。急性运动应激能使机体发生许多的生理、生化变化,心肌热休克蛋白会做出相对应的表达,对心肌细胞进行保护。低强度运动能够诱导增加热休克蛋白72基因的表达,抑制心肌细胞凋亡。大强度运动减少了热休克蛋白72基因的表达,不能有效抑制心肌细胞凋亡,不利于心肌的保护作用。中等运动强度下,热休克蛋白在不同运动时间的表达情况存在异议。运动诱导热休克蛋白表达对运动所致损伤的防护是有可能的,适量的运动活动在增强心肌功能、预防心肌在各种应激情况下的损伤具有重要作用。

Expression of myocardial heat shock protein under stress state

BACKGROUND： Heat shock proteins have unique biological characteristics, and exploration of such proteins expressed in the myocardium under exercise stress has important value. OBJECTIVE： To investigate the studies about the expression of myocardia! heat shock proteins under stress condition and analyze the expression characteristics of myocardial heat shock proteins under different stress conditions. METHODS： A computer-based online retrieval was performed to find articles about the production, classification and function of heat shock proteins, as well as the expression of myocardial heat shock proteins published from January 1991 to January 2014 in PubMed database and Wanfang databases. The key words were ＂heat shock protein; myocardium; exercise stress＂ in English and Chinese. Finally 48 relevant articles were summarized. RESULTS AND CONCLUSION： Heat shock proteins have the immune synergy effect. Researches show that,exercise training triggers the expression of myocardial heat shock protein. Acute exercise stress leads to a variety of physiological and biochemical changes, accordingly myocardial heat shock protein will make the corresponding expression and protect myocardial cells. Low-intensity exercise can increase the expression level of heat shock protein 72, and inhibit cardiomyocyte apoptosis. High-intensity exercise reduces the expression of heat shock protein 72, which can not effectively inhibit cardiomyocyte apoptosis and is not conducive to the myocardial protective effect. The expression of heat shock protein under moderate-intensity exercise remains controversial. Exercise-induced expression of heat shock protein may have protection effect against damage induced by exercise, moderate exercise activities play an important role in enhancing myocardial function and preventing myocardial injury.