酒精性脂肪肝患者胰岛素抵抗及相关代谢的研究

目的调查酒精性脂肪肝患者是否存在胰岛素抵抗及其相关的代谢紊乱。方法分析B超诊断脂肪肝患者58例,其中原发性非酒精性脂肪肝31例,酒精性脂肪肝27例,分别与22例健康体检者进行对比分析。结果与正常对照组相比,酒精性脂肪肝组的血尿酸、甘油三酯、空腹血糖、空腹胰岛素、空腹C肽水平、HOMA-IR升高,高密度脂蛋白、胰岛素敏感指数降低。酒精性脂肪肝组的血压、BMI、腰围也明显高于正常对照组。结论无论原发性非酒精性脂肪肝还是酒精性脂肪肝均存在显著的胰岛素抵抗及其相关的代谢紊乱,以及胰岛素敏感性的降低。酒精性脂肪肝患者的糖脂代谢紊乱似乎更重,嘌呤代谢异常更明显及血压更高。

Study of insulin resistance in subjects with AFLD

Objective To study whether there is the insulin resistance in subjects with alcoholic fatty liver disease.Methods 58 patients were detected.There were 31 patients were primary nonalcoholic fatty liver disease(PNAFLD),27 patients were alcoholic fatty liver disease(AFLD).There are 22 persons without abnormal metabolic indexes as controls.The levels of blood glucose,lipids,insulin and urine acid were measured in all subjects,and BP,BMI,waist circumference(WC) were detected too.Results The patients with alcoholic fatty liver disease had the higher levels of BP,BMI,WC,serum total cholesterol,TG,FPG,fasting insulin,fasting C-peptide,and HOMA-IR index than the controls,and lower levels Of HDL-C,insulin sensitivity index than the controls.Conclusion There was high metabolic disorder and insulin resistance in AFLD.There were high BP and abnormal purine metabolism in AFLD.