New conjugates of mycophenolic acid and their antiproliferative activity |
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| Authors: | Michał Prejs Grzegorz Cholewinski Agnieszka Siebert Piotr Trzonkowski |
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| Affiliation: | 1. Department of Organic Chemistry, Gdansk University of Technology, 80-233 Gdansk, Poland;2. Department of Clinical Immunology and Transplantology, Medical University of Gdansk, 80-211 Gdansk, Poland |
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| Abstract: | The new conjugates of mycophenolic acid (MPA) were obtained in the reaction of N6-(ω-aminoalkyl)adenosines with MPA in the presence of EDCI as a coupling reagent. New compounds 4a–h were evaluated on leukemia cell line (Jurkat) and PBMC from healthy donors. Length of the linker influenced observed activity. The compound 4b possessing 1,3-diamine spacer exhibited the most promising results and can be considered to further investigations. |
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| Keywords: | Mycophenolic acid MPA adenosine synthesis antiproliferative activity |
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