肝病患者血清脂蛋白(a)水平及临床意义

目的 :探讨肝病患者血清脂蛋白 (a)的水平。方法 :采用单克隆抗体浊度法测定了 341例肝病患者和 98例健康者的脂蛋白 (a)水平 ,并与总胆红素、丙氨酸氨基转移酶含量进行比较。结果 :各组肝病患者的脂蛋白 (a)平均水平均低于健康对照组。其中慢性迁延性肝炎、肝硬化、急性黄疸型肝炎、原发性肝癌的降低有非常显著差异 (P <0 .0 1)。慢性活动性肝炎的降低亦有显著性差异 (P <0 .0 5 )。急性无黄疸型肝炎和继发性肝癌的降低则无显著性意义 (P >0 .0 5 ) ;脂蛋白 (a)与总胆红素之间无明显相关 (r =0 .2 5 5 6 ) ,脂蛋白 (a)与丙氨酸氨基转移酶间则有反比关系 (r =- 0 .882 6 )。结论 :血清脂蛋白 (a)可作为肝细胞损害程度的临床判断指标之一

LEVEL OF SERUM LP(a) IN HEPATIC DISEASE PATIENTS:CLINICAL SIGNIFICANCE

Objective:To study the level of serum Lp(a) in hepatic disease patients.Methods:Monoclonal antibodies method was used to detect the level of Lp(a) in 341 hepatic disease patients and 98 healthy persons.Comparison the level with content TB and ALT.Results:The average levels of serum Lp(a) in patients with hepatic diseases in various groups were lower than healthy persons.The serum levels Lp(a) of the chronic persistent hepatitis,cirrhosis of the liver,acute jaundice hepatitis,primary carcinoma of the liver and chronic active hepatitis were significantly reduced (P<0.01 and P<0.05,respectively),acute no jaundice hepatitis and secondary carcinoma of the liver were also reduced though no statistical significance was found (P>0.05).There was no change orderliness between Lp(a) and TB(r=0.255 6).There was heve inverse ratio connection between Lp(a) and ALT(r=-0.882 6).Conclusions:Serum Lp(a) can be used as one of clinical values to judge the extent of damage to liver in patients.