Induction of apoptosis in a T lymphoblastoid cell line infected with feline immunodeficiency virus |
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| Authors: | K. Ohno Y. Okamoto T. Miyazawa T. Mikami T. Watari R. Goitsuka H. Tsujimoto A. Hasegawa |
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| Affiliation: | (1) Department of Veterinary Internal Medicine, Faculty of Agriculture, The University of Tokyo, Tokyo, Japan;(2) Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Tokyo, Japan |
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| Abstract: | Summary The mechanism of cell death induced by feline immunodeficiency virus (FIV) infection was investigated in an interleukin 2(IL-2)-dependent T-lymphoblastoid cell line (MYA-1). DNA extracted from FIV-infected MYA-1 cells showed a ladder of nucleosomal DNA, indicating that the cytopathic effect (CPE) observed in these cells was due to apoptosis. Infection of MYA-1 cells with FIV was associated with suppression of the proliferative response of the cells to exogenous IL-2 prior to DNA fragmentation. These findings suggest that FIV-induced CPE in these T-lymhoblastoid cells is associated with apoptosis possibly due to a defect in the IL-2 signal transduction pathway. |
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