Antileishmanial Activity of Natural Product‐Like Naphthoquinones期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Antileishmanial Activity of Natural Product‐Like Naphthoquinones

Authors:

Jeremiah P. Malerich Jinfang Li Dallas Joder Érica L. M. Vieria Tatjana S. L. Keesen Rajeev Vaidyanathan Kenneth J. Gollob Mary J. Tanga

Affiliation:

1. SRI International, Center for Infectious Disease and Biodefense Research, , Menlo Park, California, 94025 USA;2. SRI International, Center for Infectious Disease and Biodefense Research, , Harrisonburg, Virginia, 22802 USA;3. Biochemistry and Immunology Department, Universidade Federal de Minas Gerais, , Belo Horizonte, MG, Brazil;4. Hospital Santa Casa, Graduate Program in Biomedicine, , Belo Horizonte, MG, Brazil

Abstract:

Preclinical Research

The antileishmanial activity of compounds inspired by naphthoquinone secondary metabolites from Bignoniaceae is presented. Three structural series of compounds from a common biosynthetic pathway were evaluated against Leishmania major. Compound ( 15 ), an analog of the natural product pinnatal, was more active than amphotericin B against L. major. When tested against L. (Viannia) braziliensis and L. infantum, compound 15 showed similar activity to amphotericin B.

Keywords:

Leishmania major Leishmania brasiliensis Leishmania infantum naphthoquinones Bignoniaceae natural products

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