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| 电针对脑缺血再灌注模型大鼠海马NMDA受体2A、2B亚型表达的影响 | |
| 引用本文： | 刘晓华,沈梅红,项晓人,穆艳云,李忠仁. 电针对脑缺血再灌注模型大鼠海马NMDA受体2A、2B亚型表达的影响[J]. 辽宁中医杂志, 2011, 0(10): 2080-2082,2113 |
| 作者姓名： | 刘晓华 沈梅红 项晓人 穆艳云 李忠仁 |
| 作者单位： | 南京中医药大学第二临床医学院; |
| 基金项目： | 国家自然科学基金资助研究项目(30772836); 江苏省科技计划项目(BE2010769); 江苏省高校自然科学基金项目(09KJD360002) |
| 摘 要： | 目的:观察NMDA受体亚单位NR2A和NR2B在缺血再灌注损伤大鼠海马结构中的表达,探讨电针"百会"、"大椎"穴对神经元的保护作用。方法:将雄性SD大鼠15只随机分为假手术组、模型组、电针组,每组各5只。采用改良Longa线栓大脑中动脉法复制局灶性脑缺血再灌注模型;电针组取"百会"及"大椎"两穴,采用连续波刺激30 min,电流强度1～3 mA,频率3Hz。用免疫组织化学方法观察受损侧海马区NMDA受体2A与2B亚型表达的变化。结果:与假手术组比较,模型组NR2A蛋白表达降低(P<0.05);NR2B蛋白表达升高(P<0.05);给予电针治疗后NR2A蛋白表达升高(P<0.05);NR2B蛋白表达降低。结论:电针通过调节脑缺血再灌注受损侧海马组织神经细胞NR2A与NR2B的异常表达,发挥对神经元的保护作用。 |
| 关 键 词： | 脑缺血再灌注 电针 NMDAR 神经元 |
Effect of Electroacupuncture on Expression of N-methyl-D-aspartate Receptor Subunits NR2A and NR2B in Hippocampa of Cerebral Ischemia-reperfusion Rats |
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| LIU Xiao-hua,SHEN Mei-hong,XIANG Xiao-ren,MU Yan-yun,LI Zhong-ren. Effect of Electroacupuncture on Expression of N-methyl-D-aspartate Receptor Subunits NR2A and NR2B in Hippocampa of Cerebral Ischemia-reperfusion Rats[J]. Liaoning Journal of Traditional Chinese Medicine, 2011, 0(10): 2080-2082,2113 | |
| Authors: | LIU Xiao-hua SHEN Mei-hong XIANG Xiao-ren MU Yan-yun LI Zhong-ren |
| Affiliation: | LIU Xiao-hua,SHEN Mei-hong,XIANG Xiao-ren,MU Yan-yun,LI Zhong-ren(The Second Clinical Medical College of Naniing University of TCM,Nanjing 210029,Jiangsu,China) |
| Abstract: | Objective:To observe the expression of N-methyl-D-aspartate receptor subunits NR2A and NR2B in Hippocampa of cerebral ischemia-reperfusion(CI/R)rats,and to investigate the effect of Electroacupuncture(EA)of Baihui(GV 20)and Dazhui(GV 14) in protecting neuron.Methods:A total of 15 Sprague Dawley rats were randomly divided into sham-operation(sham),model and EA groups.CI/R model was established by right middle cerebral artery occlusion for 2 h and reperfusion for 24 h.EA(3Hz,1-3mA)was applied toBaihui(GV 20),... |
| Keywords: | cerebral ischemia-reperfusion electroacupuncture(EA) NMDA receptor neuron |
| 本文献已被 CNKI 维普 等数据库收录！ | |