生肌象皮膏中象皮作用与地位的临床研究

目的:生肌象皮膏是具有生肌长皮作用的外用代表中药之一,对溃疡期脓腐已净而皮不生、肉不长者有很好疗效。但是大象属于野生保护动物,国际组织已明确禁止捕杀,所以造成生肌象皮膏无象皮可用的局面。试从临床方面观察象皮在生肌象皮膏中的作用与地位,若象皮在生肌象皮膏中具有重要的作用与地位,则进行象皮代用品的研究。方法:慢性溃疡病人60例,随机分成两组,在基础治疗前提下,在创面腐肉已脱落时,两组分别应用生肌象皮膏与无象皮的生肌象皮膏,观察创面肉芽组织及上皮生长、创面分泌物及pH值的变化并记录。结果:治疗30天,治疗组和对照组在治疗有效率、创面脓液的质与量、创面上皮及肉芽生长、创面脓液开始分泌时间、创面上皮及肉芽组织开始生长时间、创面分泌物的pH值方面有所不同,经统计学检验,有明显差异(P<0.05)。结论:生肌象皮膏与无象皮的生肌象皮膏在临床方面差别明显,象皮在生肌象皮膏中有其独特的作用和地位,确有必要进一步寻找其代用品,使这一古老生肌长皮的传统外用药能继续得以发扬光大,造福人类。

The Clinical Research on the Important Role for the Elephant Leather on the Sheng Ji Xiang Pi Ointment

Objective ： Sheng Ji Xiang Pi Ointment, one of representative drugs of traditional Chinese medicine for external use, which has granulating functions, con treat various boils and sores, particularly to the stage of ulceration pus and carrion almost vanished, skin and muscle has not growth yet. But wild elephants belong to the protected species and has been clearly prohibited to be killed and traded by the international organization. Then the Sheng Ji Xiang Pi Ointment can not be used any more as a result of no elephant leather. We try to realize the importance of elephant leather on the Sheng Ji Xiang Pi Ointment from the clinical research. If elephant leather has an important role on the Sheng Ji Xiang Pi Ointment, then we try to make the best substitutes for elephant leather in the future. Methods ：60 patients of chronic ulcers were randomly divided＇into two groups（ treatment group and control group）. Based on the control of blood sugar, infection and blood pressure and other basic treatment, ulcer wound was treated mainly with external treatment. Only when the most carrion had been discharged from the wound, did the two groups of patients are treated with Sheng Ji Xiang Pi Ointment and Sheng Ji Xiang Pi Ointment without elephant leather respectively, recorded in detail the wound granulation, epithelialization, secretions and the pH of wound. Results ： After 30 days, there had significant difference between the two groups （ P 〈 0.05 ） on the clinical effective rate, on the quality and the quantity of wound secretion, on the epithelial growth and the growth of granulation, on the pH of wound of two groups, on the time when the wound began to secrete pus, grow epithelial and to grow fresh granulation. Conclusion ： Elephant leather had an important effect in the Sheng Ji Xiang Pi Ointment and there was significant difference between Sheng Ji Xiang Pi Ointment and the Sheng Ji Xiang Pi Ointment without elephant leather on the clinical research.