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Anti-ulcer activity of calcitonin gene-related peptide in rats |
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| Authors: | C A Maggi S Evangelista S Giuliani A Meli |
| Affiliation: | 1. Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, India;2. All India Institute of Medical Sciences, New Delhi 110029, India;1. Laboratory of Molecular Chemistry and Pharmacology, Regional University of Cariri, Rua Cel. Antonio Luis 1161, Pimenta, 63105-000 Crato (CE), Brazil;2. Laboratory of Research in Natural Products, Regional University of Cariri, Rua Cel. Antonio Luis 1161, Pimenta, 63105-000 Crato (CE), Brazil |
| Abstract: | Calcitonin gene-related peptide (CGRP, 5-10 micrograms/kg s.c.). reduced both incidence and degree of indomethacin- or acetylsalicylic acid (ASA) plus HCl-induced gastric as well as cysteamine-induced duodenal ulcers in rats. CGRP had no effect on ethanol-induced gastric lesions. The anti-ulcer activity of CGRP is most likely ascribable to its potent antisecretory properties. |
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