孕期环境暴露因素与先天性心脏病关系

目的 探讨母亲孕期环境暴露因素与子代先天性心脏病(CHD)之间的关系,为CHD的干预防治提供科学依据.方法 采用1:1配对病例对照研究,分析115对CHD患儿与对照组父母的环境暴露因素,对CHD可能的危险因素进行单因素及多因素条件Logistic回归分析.结果 母亲怀孕早期接触农药(OR=7.316,95%CI=1.196~44.731)、孕早期感冒(OR=4.806,95%CI=2.092~11.04)、妊娠合并症(OR=2.851,95%CI=1.189~6.838)、孕期情绪状况(OR=3.318,95%CI=1.829~6.018)4个因素为子代发生CHD的危险因素.结论 母亲怀孕早期接触农药、孕早期感冒、孕期患妊娠合并症、孕期情绪紧张或忧郁可能增加子代发生CHD的危险.

Study on relationship between environmental factors in pregancy and congenital heart diseases

Objective To explore congenital heart diseases(CHD)in offspring in association with maternal environmental factors.Methods A 1:1 case-control study was carried out to investigate 115 pairs children and their parents.The possible risk factors were analysed by simple and multiple factors Logistic regression.Results 4 factors were related with the occurrence of CHD in offspring:maternal exposures to pesticides in the early stage of pregnancy(OR=7.316,95%CI:1.196～ 44.731),catching a cold in the early stage of pregnancy(O R=4.806,95%CI:2.092～1.104),suffering from diseases during pregnancy(OR=2.851,95%CI=1.189～6.838),depressed or nervous condition during pregnancy(OR=3.318,95%CI=1.829～6.018).Conclusion The occurrence of CHD was related with maternal exposures to pesticides,catching a cold,suffering from diseases,depressed or nervous condition in the early stage of pregnancy or during the pregnancy.