中晚期肿瘤患者T淋巴细胞和NK细胞检测的临床意义

目的分析中晚期恶性肿瘤患者外周血T淋巴细胞表型和NK细胞测定值的特点、影响因素及其临床意义。方法采用流式细胞术（FCM）检测60例实体肿瘤患者和30例健康人外周血中T淋巴细胞表型和NK细胞的变化。结果中晚期恶性肿瘤患者CD3^＋、CIM^＋、NK16＋56^＋百分率下降，CD8^＋百分率升高，CIM^＋／CD8^＋比值降低，上述指标与健康人比较，差异有统计学意义（P〈0．05）；患者性别、年龄、肿瘤的部位及病理类型不影响其表达，差异无统计学意义（P〉0．05），结论中晚期肿瘤患者存在细胞免疫功能下降，临床上应对中晚期肿瘤患者提供积极的免疫辅助治疗。

Clinical Significance of T Lymphocyte and NK Cell Detection in Patients with Advanced Malignant Tumor

Objective To investigate the character,affecting factor and clinical significance of the detection value of T lymphocytes sub-group and natural killer (NK) cells in peripheral blood of patients with advanced malignant tumor.Methods T lymphocyte sub-group and NK cells in peripheral blood of 60 patients with advanced malignant tumor (patient group) and 30 normal individuals (control group) were detected by flow cytometry (FCM).Results In the patient group,the percentage of CD3 ,CD4 and NK16 56 decreased and CD8 increased,the value of CD4 /CD8 decreased.There was significant difference between the two groups (P<0.05).The age and sexuality of patients,the region and category of tumor didn't influence the expression of T lymphocyte sub-group and NK (P<0.05).Conclusions The function of cellular immunity is abnormal in patients with advanced malignant tumor.It is of active significance for the choice of immune therapy.