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Cerebrovascular events during pregnancy and puerperium
Authors:M. Yger  D. Weisenburger-Lile  S. Alamowitch
Affiliation:1. Stroke unit, Saint-Antoine hospital, APHP, Sorbonne Université, 184, rue du Faubourg Saint-Antoine, 75012 Paris, France;2. Unité INSERM U938 centre de recherche Saint Antoine, Université Sorbonne Paris;1. CHU de Rennes, Neurology department, 2, Rue Henri-le-Guilloux, 35000 Rennes, France;2. University Rennes, Inria, CNRS, Inserm, IRISA UMR 6074, Empenn U1228, Rennes, France;3. CHU de Rennes, Radiology department, Rennes, France;1. Department of Neurology, John Hunter Hospital, University of Newcastle, Newcastle, Australia;2. Hunter Medical Research Institute and University of Newcastle, Newcastle, Australia;3. Acute stroke unit, CHU Toulouse Purpan, Toulouse, France;4. Toulouse neuroimaging centre, Toulouse, France;5. Neurology Department, GHU Paris psychiatrie et neurosciences, Sainte-Anne Hospital, Université de Paris, INSERM UMR 1266, Paris, France;6. Department of Neurology, Melbourne Brain Centre at the Royal Melbourne Hospital, University of Melbourne, Parkville, Australia;1. Department of interventional Neuroradiology, Fondation Rotschild, Paris, France;2. Department of Diagnostic and Therapeutic Neuroradiology, Hôpital Foch, Suresnes, France
Abstract:
Though cerebrovascular complications of pregnancy remain relatively rare, they represent a potentially devastating event that necessitates prompt identification and treatment. Eighteen percent of strokes occurring in young women are linked to pregnancy. They occur mostly in the third trimester or during the post-partum period. Their biggest risk factors are hypertension, preeclampsia/eclampsia and migraine. Cerebrovascular events occurring during this period may involve specific pathophysiological processes that include embolic phenomena or endothelial dysfunction, but can also have common etiologies that are simply favored by the context of pregnancy. Thus, posterior encephalopathy and vasoconstriction cerebral syndrome are relatively frequently involved in cerebrovascular complications of pregnancy. Other very specific causes like amniotic fluid embolism or postpartum cardiomyopathy can also be responsible for such events. The management of stroke during pregnancy must be multidisciplinary and include a neurovascular expertise. Some conditions can lead to a long-life follow-up and modify the management of a future pregnancy.
Keywords:Preeclampsia  Pregnancy  Stroke  Endothelial dysfunction  PRES  RCVS  Migraine  CVT"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0045"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  cerebral venous thrombosis  PE"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0055"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  preeclampsia  AFE"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0065"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  amniotic fluid embolism  PPCM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0075"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  postpartum cardiomyopathy  PRES"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0085"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  posterior reversible encephalopathy syndrome  RCVS"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0095"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  reversible cerebral vasoconstriction syndrome  PFO"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0105"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  patent foramen ovale  CT"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0115"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  computed tomography  MRI"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0125"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  magnetic resonance imaging  AVM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0135"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  arteriovenous malformation  SAH"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0145"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  subachanoid hemorrhage  CCM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0155"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  cerebral cavernous malformation  FLAIR"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0165"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  fluid-attenuated inversion recovery  CSF"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0175"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  cerebrospinal fluid  HDP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0185"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  hypertensive disorders during pregnancy  LOCM"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0195"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  Low-osmolality contrast media  HELLP"  },{"  #name"  :"  keyword"  ,"  $"  :{"  id"  :"  kw0205"  },"  $$"  :[{"  #name"  :"  text"  ,"  _"  :"  (H=HemolysisEL=Elevated Liver enzymes, LP=Low Platelets)
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