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Sputum microbiome profiles identify severe asthma phenotypes of relative stability at 12 to 18 months |
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| Authors: | Mahmoud I. Abdel-Aziz Paul Brinkman Susanne J.H. Vijverberg Anne H. Neerincx John H. Riley Stewart Bates Simone Hashimoto Nazanin Zounemat Kermani Kian Fan Chung Ratko Djukanovic Sven-Erik Dahlén Ian M. Adcock Peter H. Howarth Peter J. Sterk Aletta D. Kraneveld Anke H. Maitland-van der Zee |
| Affiliation: | 1. Department of Respiratory Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, The Netherlands;2. Department of Clinical Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt;3. Respiratory Therapeutic Unit, GlaxoSmithKline, Stockley Park, United Kingdom;4. Department of Pediatric Respiratory Medicine, Emma Children''s Hospital, Amsterdam UMC, Amsterdam, The Netherlands;5. Data Science Institute, Imperial College London London, United Kingdom;6. National Heart and Lung Institute, Imperial College London, and Royal Brompton and Harefield NHS Trust, London, United Kingdom;7. NIHR Southampton Respiratory Biomedical Research Unit, Clinical and Experimental Sciences and Human Development and Health, University of Southampton, Southampton, United Kingdom;8. Centre for Allergy Research, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden;9. Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of Science, Utrecht University, Utrecht, The Netherlands;10. Institute for Risk Assessment Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands |
| Abstract: |  |
| Keywords: | Sputum microbiome metagenomics asthma phenotypes unbiased clusters follow-up neutrophils macrophages lung function FDR" },{" #name" :" keyword" ," $" :{" id" :" kwrd0055" }," $$" :[{" #name" :" text" ," _" :" False discovery rate PAM" },{" #name" :" keyword" ," $" :{" id" :" kwrd0065" }," $$" :[{" #name" :" text" ," _" :" Partition around the medoids RI" },{" #name" :" keyword" ," $" :{" id" :" kwrd0075" }," $$" :[{" #name" :" text" ," _" :" Rand index rRNA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0085" }," $$" :[{" #name" :" text" ," _" :" Ribosomal ribonucleic acid TDA" },{" #name" :" keyword" ," $" :{" id" :" kwrd0095" }," $$" :[{" #name" :" text" ," _" :" Topological data analysis U-BIOPRED" },{" #name" :" keyword" ," $" :{" id" :" kwrd0105" }," $$" :[{" #name" :" text" ," _" :" Unbiased Biomarkers in Prediction of Respiratory Disease Outcomes |
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