Early administration of amatuximab,a chimeric high-affinity anti-mesothelin monoclonal antibody,suppresses liver metastasis of mesothelin-expressing pancreatic cancer cells and enhances gemcitabine sensitivity in a xenograft mouse model |
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| Authors: | Fujii Yuki Kamachi Hirofumi Matsuzawa Fumihiko Mizukami Tatsuzo Kobayashi Nozomi Fukai Moto Taketomi Akinobu |
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| Affiliation: | 1.Department of Gastroenterological Surgery 1, Hokkaido University Graduate School of Medicine, N15W7, Kitaku, Sapporo, Hokkaido, 060-8638, Japan
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| Abstract: | Investigational New Drugs - Amatuximab is a promising therapeutic antibody targeting mesothelin, a 40-kDa glycoprotein that is highly expressed in pancreatic cancer. We investigated the... |
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