MRI characteristics of MOG-Ab associated disease in adults: An update |
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| Authors: | N. Shor R. Deschamps A. Cobo Calvo E. Maillart H. Zephir J. Ciron C. Papeix F. Durand-Dubief A. Ruet X. Ayrignac M. Cohen K. Deiva D. Laplaud B. Bourre B. Audoin N. Collongues S. Vukusic F. Cotton R. Marignier |
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| Affiliation: | 1. Department of Neurology, Toyohashi Municipal Hospital, Aichi, Japan;2. Department of Neurology, Okazaki City Hospital, Aichi, Japan;3. Department of Neurology, Toyama University Hospital, Toyama, Japan;4. Department of Neurology, Tohoku University Graduate School of Medicine, Miyagi, Japan;5. Department of Neurology, National Hospital Organization Yonezawa Hospital, Yamagata, Japan;6. Department of Neurology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan;1. Department of Child Neurology, University of California San Francisco, San Francisco, CA, United States;2. Department of Neurology, University of California San Francisco, San Francisco, CA, United States;3. Department of Ophthalmology, University of California San Francisco, San Francisco, CA, United States |
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| Abstract: | ![]()
Our knowledge of the radiological spectrum of myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD) is growing rapidly. An update on the radiological features of the disease, and its evolution is thus necessary. Magnetic resonance imaging (MRI) has an increasingly important role in the differential diagnosis of MOGAD particularly from aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD), and multiple sclerosis (MS). Differentiating these conditions is of prime importance because the management is different between the three inflammatory diseases, and thus could prevent further attack-related disability. Therefore, identifying the MRI features suggestive of MOGAD has diagnostic and prognostic implications. We herein review optic nerve, spinal cord and the brain MRI findings from MOGAD adult patients, and compare them to AQP4-NMOSD and MS. |
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| Keywords: | Imaging Myelin Oligodendrocyte Glycoprotein Aquaporin-4 Neuromyelitis Optica Optic neuritis Myelitis MOGAD" },{" #name" :" keyword" ," $" :{" id" :" kw0040" }," $$" :[{" #name" :" text" ," _" :" MOG-Ab associated disease AQP4-NMOSD" },{" #name" :" keyword" ," $" :{" id" :" kw0050" }," $$" :[{" #name" :" text" ," _" :" aquaporin-4 antibody neuromyelitis optica spectrum disorder Ab" },{" #name" :" keyword" ," $" :{" id" :" kw0060" }," $$" :[{" #name" :" text" ," _" :" antibody MS" },{" #name" :" keyword" ," $" :{" id" :" kw0070" }," $$" :[{" #name" :" text" ," _" :" multiple sclerosis ADEM" },{" #name" :" keyword" ," $" :{" id" :" kw0080" }," $$" :[{" #name" :" text" ," _" :" acute disseminated encephalomyelitis ON" },{" #name" :" keyword" ," $" :{" id" :" kw0090" }," $$" :[{" #name" :" text" ," _" :" optic neuritis OPN" },{" #name" :" keyword" ," $" :{" id" :" kw0100" }," $$" :[{" #name" :" text" ," _" :" Optic perineuritis VA" },{" #name" :" keyword" ," $" :{" id" :" kw0110" }," $$" :[{" #name" :" text" ," _" :" visual acuity SM" },{" #name" :" keyword" ," $" :{" id" :" kw0120" }," $$" :[{" #name" :" text" ," _" :" short myelitis LETM" },{" #name" :" keyword" ," $" :{" id" :" kw0130" }," $$" :[{" #name" :" text" ," _" :" longitudinally extensive transverse myelitis CLIPPERS" },{" #name" :" keyword" ," $" :{" id" :" kw0140" }," $$" :[{" #name" :" text" ," _" :" chronic lymphocytic inflammation with pontine perivascular enhancement responsive to steroids GFAP" },{" #name" :" keyword" ," $" :{" id" :" kw0150" }," $$" :[{" #name" :" text" ," _" :" glial fibrillary acidic protein NMDAr" },{" #name" :" keyword" ," $" :{" id" :" kw0160" }," $$" :[{" #name" :" text" ," _" :" N-methyl-D-aspartate receptor AMPAr" },{" #name" :" keyword" ," $" :{" id" :" kw0170" }," $$" :[{" #name" :" text" ," _" :" amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor GABAr" },{" #name" :" keyword" ," $" :{" id" :" kw0180" }," $$" :[{" #name" :" text" ," _" :" and gamma-aminobutyric acid receptor DWI" },{" #name" :" keyword" ," $" :{" id" :" kw0190" }," $$" :[{" #name" :" text" ," _" :" diffusion weighted imaging PSIR" },{" #name" :" keyword" ," $" :{" id" :" kw0200" }," $$" :[{" #name" :" text" ," _" :" phase-sensitive inversion-recovery MPRAGE" },{" #name" :" keyword" ," $" :{" id" :" kw0210" }," $$" :[{" #name" :" text" ," _" :" magnetization-prepared rapid gradient echo 3D" },{" #name" :" keyword" ," $" :{" id" :" kw0220" }," $$" :[{" #name" :" text" ," _" :" 3-Dimentional |
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