Influence of pigment epithelial detachment on visual acuity in neovascular age-related macular degeneration |
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| Authors: | Kai Xiong Cheong Kelvin Yi Chong Teo Chui Ming Gemmy Cheung |
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| Affiliation: | 1. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore;2. Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore;1. Cornea, Cataract and Refractive Surgery Unit, Vissum (Miranza Group), Alicante, Spain;2. Division of Ophthalmology, Universidad Miguel Hernández, Alicante, Spain;3. Cornea Unit, Guy''s & St Thomas'' Hospital, London, UK;4. Singapore Eye Research Institute, Singapore National Eye Centre, Singapore;5. Department of Ophthalmology and Visual Science, Duke-NUS Graduate Medical School, Singapore;6. Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand;7. Jules Gonin Eye Hospital, University of Lausanne, Lausanne, Switzerland;8. External Disease Service, Moorfields Eye Hospital, London, UK;1. Department of Ophthalmology, University of Warmia and Mazury, Olsztyn, Poland;2. Institute for Research in Ophthalmology, Poznan, Poland;3. Department of Ophthalmology, Poznan City Hospital, Poznan, Poland;4. Department of Ophthalmology, Hospital de Clínicas, Universidad de Buenos Aires, Argentina;5. Department of Ophthalmology, Mayo Clinic Florida, Jacksonville, FL, USA;1. Casey Eye Institute, Oregon Health & Science` University, Portland, OR, USA;2. Portland VA Healthcare System, Portland, OR, USA;3. The Department of Ophthalmology, California Pacific Medical Center, San Francisco, CA, USA;4. The Department of Ophthalmology, Stanford University School of Medicine, San Francisco, CA, USA;5. The Francis I. Proctor Foundation, UCSF School of Medicine, San Francisco, CA, USA;6. West Coast Retina Medical Group, San Francisco, CA, USA;7. Vitreous Retina Macula Consultants of New York, New York, NY, USA;8. LuEsther T. Mertz Retinal Research Center, Manhattan Eye, Ear and Throat Hospital, New York, NY, USA;9. Department of Ophthalmology, New York University Langone Medical Center, New York, NY, USA;10. Department of Ophthalmology, Columbia University, New York, NY, USA;1. University of Wroc?aw, Clinic of Ophthalmology, Wroc?aw, Poland;2. Carl-Thiem-Klinikum, Klinik für Dermatologie und Allergologie, Cottbus, Germany;3. Provincial Specialist Hospital in Wroc?aw, Clinic of Ophthalmology, Wroc?aw, Poland |
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| Abstract: | Pigment epithelial detachment (PED), the anatomical separation of the retinal pigment epithelium from the Bruch membrane, is common in many chorioretinal diseases, including neovascular age-related macular degeneration. PED is present in about 30% to 80% of neovascular age-related macular degeneration patients based on the CATT, EXCITE, and VIEW studies. The influence of PED on visual acuity is controversial as a result of inconsistent results reported by various studies. With advances in imaging technologies, it is possible to evaluate not only the presence or absence of PED, but also detailed quantitative parameters, such as height, width, greatest linear diameter, area, volume, and reflectivity within the PED. We performed a comprehensive literature review to evaluate the relationship of PED with visual acuity. In summary, the presence or persistence of a PED may still be compatible with relatively good visual acuity. There is no strong evidence that the presence of a PED or aspects of its morphology has a significant impact on visual acuity. The presence of a PED may be predictive of the need for more regular treatment. More well-designed studies with standardized PED definitions and classifications are needed to evaluate the relationship between PED and visual acuity. |
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| Keywords: | pigment epithelial detachment(s) age-related macular degeneration neovascular age-related macular degeneration choroidal neovascularisation anti-VEGF bevacizumab ranibizumab aflibercept visual acuity vision |
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