Current concepts in the pathophysiology and management of diabetic ketoacidosis |
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| Authors: | P. S. N. Menon M. D. R. K. Menon M. D. A. Gupta M. D. |
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| Affiliation: | (1) Department of Pediatrics, All-India institute of Medical Sciences, 110029 New Delhi |
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| Abstract: | Recent studies indicate that for the development of diabetic ketoacidosis glucagon excess is essential in addition to a deficiency of insulin. Glucagon activates the carnitine acyl transferase I leading to ketonemia. Low dose continuous infusion of insulin appears to be the ideal mode of therapy for the correction of hyperglycemia. The use of sodium bicarbonate and phosphate as adjuvants in management is discussed in the light of recent observations. |
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| Keywords: | Diabetic ketoacidosis low dose continuous insulin therapy |
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