MR对非酒精性脂肪肝的评价

目的：评价MRI对非酒精性脂肪肝（NAFLD）的价值。方法：45例肥胖患者行MR T1dual和1H-MRS检查,评价这两种方法计算NAFLD含量临界值的意义,并与CT检查作对照。结果：MR T1dual HFF、RSID及1H-MRS等方法与CT评价脂肪肝程度的相关系数分别为-0.951、-0.935、-0.659（P〈0.01）。且各种评价方法分别与TG、GGT指标显著相关,其中RSID与TG、GGT相关性最好（r=0.406、0.457,P〈0.01）,而1H-MRS所评价的肝内脂质含量分别与ALT、TG及GGT之间有对数的线性关系。结论：MRI T1dual是一种方便、快速、安全的定量检查NAFLD方法,HFF9%、RSID 20%可作为有无肝内脂肪浸润的指标。MR T1dual中RSID及^1H-MRS可以很好的评价肝内TG水平。

Evaluation study of MRI on non-alcoholic fatty liver disease

Objective：To evaluate the clinical value of MRI on non-alcoholic fatty liver disease（NAFLD）.Methods：Forty-five obesity patients underwent in-phase/opposed-phase（IP/OP） magnetic resonance imaging and 1H-magnetic resonance spectroscopy（1H-MRS）,we try to find the cut-off point of NAFLD detected by MRI according to the hepatic steatosis severity by CT.Results：Compared with CT,the coefficient correlation of IP/OP MRI hepatic fat fraction（HFF）,relative signal intensity decrease（RSID） by MRI and intrahepatocellular lipids of 1H-MRS were-0.951,-0.935,-0.659（P〈0.01）.The hepatic steatosis severity of all methods above were significantly correlate with TG and GGT.In which,RSID was the most correlated parameter（r=0.406,0.457,P〈0.01）.Linear regression analysis was conducted on a log-log scale among the 1H-MRS and ALT,TG and GGT.Conclusion：IP/OP MRI is a convenient,fast,and safe technique,which can detect and quantify liver steatosis.A diagnosis of fatty liver was established with HFF≥9%,RSID≥20%.RSID criterion and intrahepatocellular lipids of ^1H-MRS facilitated the correct prediction of the concentration of TG.