17例双硫伦样反应临床分析

目的探讨双硫伦样反应的发生特点,引起临床医护人员的重视,避免误诊。方法对本院2005年5月～2007年6月发生的17例双硫伦样反应的病例资料进行回顾性分析,总结其发生的原因、诱因、临床表现、治疗转归,误诊等。结果①双硫伦样反应见于各种原发病患者;②导致双硫伦样反应的患者以使用头孢菌素类抗生素为主;占94.12%;③双硫伦样反应的患者以接触酒类和乙醇制剂为主要诱因;④临床表现有颜面潮红、头痛、胸闷、心悸、恶心呕吐、烦躁、气促、低血压、呼吸困难;⑤双硫伦样反应一般出现在饮酒后20～60min;⑥对症治疗后临床症状在30～120min内缓解。结论对使用头孢菌素药物患者应重视双硫伦样反应的发生,治疗过程前后应特别医嘱避免饮酒和使用乙醇制剂。

Clinical analysis to 40 disulfiram-like reactions

Objective To arouse the the recognition of clinical personnel and avoid false diagnoses by discussing the producing feature of disulfiram-like reactions.Method To analysis the medical record of 17 cases with disulfiram-like reactions from May,2005 to June,2007 and summarize the producing reasons,inducement,clinical exhibition,curing,lapsing diagnoses.Result The disulfiram-like reactions were happened on the cases of primary affection.The application of cephalosporin can arose the 94.12 percents of disul-firam-like reactions.The primary inducement of disulfiram-like reactions was to touch the ethanol and happened on 20 to 60 minutes after touthing the ethanol.The clinical exhibition of disulfiram-like reactions were rubefaction,head aching,irritancy,nausea,breathe hard,low blood pressure.which was catabatic on 30 to 120 minutes after the clinical therapy.Conclusion We should attach importance to disulfiram-like reactions on the using of cephalosporin and avoid the touth of ethanol around the clinical therapy.