中国首次基孔肯雅热流行患者的临床特点

目的 分析基孔肯雅热患者的临床特点,为防控该病提供借鉴.方法 分析46例确诊为基孔肯雅热的住院患者的临床症状、体征.血常规,生物化学指标以及治疗方案.组间比较采用t检验.结果 46例基孔肯雅热患者中,发热、皮疹及关节痛分别为46、42和41例,分别占100.0%、91.3%和89.1%;15例患者外周血WBC下降,占32.6%,乳酸脱氢酶及血清磷酸肌酸激酶升高比例分别为45.5%(20/44)和28.9%(13/45),3例ALT升高.利巴韦林治疗与单纯对症治疗效果相比,发热时间延长(t=2.588,P=0.013).结论 基孔肯雅热主要表现为发热、皮疹、关节痛,对症治疗预后好,抗病毒治疗对缩短病程可能无益.

Abstract：

Objective To analyze clinical features of patients with chikungunya fever and provide future reference for prevention and control of the disease. Methods Forty-six confirmed chikungunya fever inpatients were included. Their clinical symptoms, signs, blood count, key biochemical indicators and treatments were analyzed. The comparison between groups were done by ttest. Results The percentages of total cases presenting with fever, rash and joint pain were 100. 0% (46/46), 91. 3% (42/46) and 89. 1% (41/46), respectively. Fifteen (32.6%) cases displayed leucopenia. Increases in lactose dehydrogenase (LDH) and creatine kinase (CK) were observed in 45. 5%(20/44) and 28. 9%(13/45) of the cases, respectively. Three cases displayed an increase of alanine aminotransferase (ALT). Administration of ribavarin extend febrile time compared to symptom-relieving treatments (t=2. 588, P = 0. 013). Conclusions Clinical features of chikungunya fever include fever, rash and joint pain. Good prognosis can be resulted from symptom-relieving treatment. Antiviral treatment may not be beneficial to reducing course of disease.

Clinical features of inpatients in the first chikungunya fever epidemic in China

Objective To analyze clinical features of patients with chikungunya fever and provide future reference for prevention and control of the disease. Methods Forty-six confirmed chikungunya fever inpatients were included. Their clinical symptoms, signs, blood count, key biochemical indicators and treatments were analyzed. The comparison between groups were done by ttest. Results The percentages of total cases presenting with fever, rash and joint pain were 100. 0% (46/46), 91. 3% (42/46) and 89. 1% (41/46), respectively. Fifteen (32.6%) cases displayed leucopenia. Increases in lactose dehydrogenase (LDH) and creatine kinase (CK) were observed in 45. 5%(20/44) and 28. 9%(13/45) of the cases, respectively. Three cases displayed an increase of alanine aminotransferase (ALT). Administration of ribavarin extend febrile time compared to symptom-relieving treatments (t=2. 588, P = 0. 013). Conclusions Clinical features of chikungunya fever include fever, rash and joint pain. Good prognosis can be resulted from symptom-relieving treatment. Antiviral treatment may not be beneficial to reducing course of disease.