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| 溶血磷脂酸受体在卵巢癌细胞系3AO、OVCAR3、SKOV3及卵巢癌组织中的表达 | |
| 引用本文： | 刘红,房朝晖,王娟,吴小华. 溶血磷脂酸受体在卵巢癌细胞系3AO、OVCAR3、SKOV3及卵巢癌组织中的表达[J]. 现代妇产科进展, 2008, 17(10): 741-744 |
| 作者姓名： | 刘红 房朝晖 王娟 吴小华 |
| 作者单位： | 1. 河北医科大学第四医院,妇瘤科,石家庄,050011 2. 河北医科大学第四医院,妇产科,石家庄,050011 |
| 基金项目： | 国家自然科学基金，河北省科学技术研究及发展计划指导性项目 |
| 摘 要： | 目的:研究溶血磷脂酸受体在人卵巢癌细胞系和人卵巢癌组织中蛋白的表达。方法:用免疫细胞化学和免疫组织化学法检测LPA1,LPA2和LPA3蛋白在人卵巢癌细胞系3AO、OVCAR3、SKOV3和人卵巢癌组织中的表达水平。结果:免疫细胞化学显示LPA1,LPA2和LPA3蛋白在人卵巢癌细胞系中均有表达;免疫组织化学显示LPA1蛋白在正常卵巢上皮和卵巢良性肿瘤中高表达,LPA2和LPA3蛋白在人卵巢癌组织中高表达。结论:LPA1,LPA2和LPA3在人卵巢癌细胞系和人卵巢癌组织中均有广泛表达;LPA2,LPA可能与卵巢癌的发生发展密切相关。 |
| 关 键 词： | 受体,溶血磷脂酸 卵巢肿瘤 细胞系 |
Expression of lysophosphatidic acid receptor in human ovarian cancer cell fines 3AO、SKOV3、OVCAR3 and in human epithelial ovarian neoplasms |
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| Liu Hong,Fang Zhaohui,Wang Juan,et al.. Expression of lysophosphatidic acid receptor in human ovarian cancer cell fines 3AO、SKOV3、OVCAR3 and in human epithelial ovarian neoplasms[J]. Current Advances In Obstetrics and Gynecology, 2008, 17(10): 741-744 | |
| Authors: | Liu Hong Fang Zhaohui Wang Juan et al. |
| Affiliation: | Liu Hong1,Fang Zhaohui1,Wang Juan2,et al.1.Department of Gynecologic Oncology,2.Department of Obstetrics and Gynecology,Fourth Affiliated Hospital,Hebei Medical University,Shijiazhuang 050011 |
| Abstract: | Objective:To investigate the expression of lysophosphatidic acid(LPA)receptors at protein levels in different human ovarian cancer cell lines and in human epithelial ovarian neoplasms.Methods:The immunocytochemical methods were employed to measure the expression of LPA1,LPA2 and LPA3 protein in cultured human ovarian cancer cell lines 3AO,OVCAR3,SKOV3 and in human epithelial ovarian neoplasms.Results:All the ovarian cancer cell lines and human epithelial ovarian neoplasms expressed LPA1,LPA2 and LPA3 proteins.LPA1 expression rates significantly decreased in cancer compared to those in non-cancerous state(P<0.05).LPA2,LPA3 expression rates significantly increased in cancer compared to those in non-cancerous state(P<0.05).Conclusion:LPA1,LPA2 and LPA3 protein express widely in all the ovarian cancer lines and in human epithelial ovarian neoplasms.Expression levels of LPA2,LPA3 may be related to invasion and metastasis of human epithelial ovarian cancer. |
| Keywords: | Receptors lysophosphatidic Ovarian neoplasms Cell line |
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