Glioblastoma multiforme of the hippocampus in advanced Alzheimer's disease |
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Authors: | E C POOLE J J KEPES |
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Institution: | Department of Pathology and Oncology, University of Kansas College of Health Sciences and Hospital, Kansas City. |
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Abstract: | An 87-year-old woman suffered from Alzheimer's disease diagnosed 6 years prior to her death. Autopsy showed in addition to far-advanced Alzheimer's disease, a large, partially necrotic glioblastoma occupying her right hippocampus. Occurrence of a glial neoplasm in Alzheimer's disease could well be coincidental, since both entities are fairly common in elderly individuals; it is however, uncommon for gliomas to centre on the hippocampus itself. For these reasons it is possible (although cannot be proven from a single case), that florid reactive gliosis commonly associated with Alzheimer's disease, may have played a role in eventually initiating neoplastic proliferation of astrocytes in this patient. |
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Keywords: | Alzheimer's disease glioblastoma hippocampus |
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