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The sentinel node biopsy in early gastric cancer: a preliminary study
Authors:Gianni Mura  Alessio Vagliasindi  Massimo Framarini  Paolo Mazza  Gabriele Solfrini  Giorgio M. Verdecchia
Affiliation:(1) Division of Surgery and Advanced Cancer Therapies, Morgagni Hospital-Forlì (Italy), Via Forlanini, 47100 Forlì, Italy;(2) Present address: Via Cimabue, 19-52100 Arezzo, Italy
Abstract:Background and aims Sentinel node biopsy is currently used in surgery of malignant melanoma and breast cancer. The feasibility of sentinel node mapping in gastrointestinal cancers and its diagnostic sensitivity is unclear. It could be of particular value in the management of early gastric cancer in which radical D2 lymphadenectomy may be unnecessary. Materials and methods From January 2004 to June 2005, ten patients with preoperative diagnosis of early gastric cancer and no nodal involvement (cT1N0) were submitted to sentinel node biopsy using the dual mapping procedure with endoscopic blue dye and 99mTc radio colloid injection. All the patients underwent standard radical gastrectomy and D2 lymphadenectomy. The resected nodes were evaluated by routine (hematoxylin–eosin) histopathological examination; the sentinel (blue or hot) nodes, in addition, were evaluated with immunohistochemistry for cytokeratin. Results The detection rate of this procedure was 100%. The preliminary results and perspectives for feasibility of sentinel node biopsy and its accuracy in predicting the nodal status in early gastric cancer are discussed.
Keywords:Gastric cancer  Sentinel node  Lymphadenectomy
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