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| 无花果内生真菌FL10中吲哚二酮哌嗪类生物碱的研究 | |
| 引用本文： | 张弘弛,刘瑞,周凤,王润梅,张航涛,马养民. 无花果内生真菌FL10中吲哚二酮哌嗪类生物碱的研究[J]. 中国实验方剂学杂志, 2013, 19(18): 95-98 |
| 作者姓名： | 张弘弛 刘瑞 周凤 王润梅 张航涛 马养民 |
| 作者单位： | 1. 山西大同大学农学与生命科学学院,山西大同,037009 2. 兵器工业卫生研究所,西安,710065 3. 陕西科技大学化学与化工学院,西安,710021 |
| 基金项目： | 高校博士点基金项目(20116125110001);山西省科技攻关项目(20100311092-1) |
| 摘 要： | 目的:研究无花果内生真菌FL10的次级代谢产物成分.方法:采用反复硅胶柱色谱法、Sephadex LH-20凝胶色谱法等进行分离纯化,从无花果内生真菌FL10的发酵液中分离得到6个吲哚二酮哌嗪类生物碱.结果:通过理化常数测定和光谱分析,6个吲哚二酮哌嗪类生物碱鉴定分别为verruculogen(1),cyclotryprostatins B(2),fumitremorgin C(3),cyclotryprostatin A(4),tryprostatin A(5),tryprostatin B(6).结论:这6个吲哚二酮哌嗪类生物碱是首次从无花果内生真菌中分离得到,目前研究表明,无花果内生真菌Aspergillus tamarii可以作为一种可产生吲哚二酮哌嗪类生物碱的新来源. |
| 关 键 词： | 内生真菌 无花果 吲哚二酮哌嗪 生物碱 |
| 收稿时间： | 2012-01-03 |
Indolyl Diketopiperazine Alkaloids Isolated from Endophyic Fungus FL10 of Ficus carica |
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| ZHANG Hong-chi,LIU Rui,ZHOU Feng,WANG Run-mei,ZHANG Hang-tao and MA Yang-min. Indolyl Diketopiperazine Alkaloids Isolated from Endophyic Fungus FL10 of Ficus carica[J]. China Journal of Experimental Traditional Medical Formulae, 2013, 19(18): 95-98 | |
| Authors: | ZHANG Hong-chi LIU Rui ZHOU Feng WANG Run-mei ZHANG Hang-tao MA Yang-min |
| Affiliation: | College of Agronomy and Life Science, Shanxi Datong University, Datong 037009, China;College of Agronomy and Life Science, Shanxi Datong University, Datong 037009, China;College of Agronomy and Life Science, Shanxi Datong University, Datong 037009, China;College of Agronomy and Life Science, Shanxi Datong University, Datong 037009, China;Institute of Health in Ordnance Industry, Xi'an 710065, China;College of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi'an 710021, China |
| Abstract: | Objective: To study chemical constituents from endophytic fungus FL10 of Ficus carica. Method: The compounds were isolated by column chromatography and identified on the basis of physic-chemical constants and spectral analysis. Result: Six indolyl diketopiperazines alkaloid were obtained and elucidated as verruculogen (1), cyclotryprostatins B (2). fumitremorgin C (3), cyclotryprostatin A (4), tryprostatin A (5), tryprostatin B (6). Conclusion: Six indolyl diketopiperazine alkaloids were isolated from endophyic fungus of F. carica for the first time. The present study revealed that endophytic fungi Aspergillus tamarii from F. carica are the sources for the production of indolyl diketopiperazine alkaloids. |
| Keywords: | endophytic fungus Ficus carica indolyl diketopiperazine alkaloid |
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