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| 对锂-匹罗卡品致颞叶癫痫模型大鼠学习记忆功能影响的研究 | |
| 引用本文： | 张加权,吴丽萍,孟陆亮. 对锂-匹罗卡品致颞叶癫痫模型大鼠学习记忆功能影响的研究[J]. 中医儿科杂志, 2013, 9(2): 10-13 |
| 作者姓名： | 张加权 吴丽萍 孟陆亮 |
| 作者单位： | 1. 甘肃中医学院,甘肃兰州,730000 2. 甘肃中医学院附属医院,甘肃兰州,730020 3. 陕西渭南职业技术学院医学院,陕西渭南,714000 |
| 基金项目： | 甘肃省中医药英才基金项目（编号GZK-2010-61） |
| 摘 要： | 目的:探讨锂-匹罗卡品致颞叶癫痫模型大鼠自发性癫痫发作后学习记忆功能障碍的情况.方法:建立锂-匹罗卡品颞叶癫痫模型,应用Morris水迷宫和八臂迷宫实验评价颞叶癫痫模型大鼠自发性癫痫发作后的学习记忆功能障碍.结果:颞叶癫痫模型大鼠自发性癫痫发作后,Morris水迷宫和八臂迷宫实验均出现不同程度的障碍,障碍程度随着自发性癫痫发作时间延长而加重.结论:锂-匹罗卡品诱导颞叶癫痫长期自发性癫痫发作后会出现明显的学习记忆功能障碍. |
| 关 键 词： | 锂-匹罗卡品 颞叶癫痫 学习记忆功能 大鼠 |
Research the influences of Lithium-Pilocarpine to learning and memory function in rat model of temporal lobe epilepsy |
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| Zhang Jiaquan , Wu Liping , Meng Luliang. Research the influences of Lithium-Pilocarpine to learning and memory function in rat model of temporal lobe epilepsy[J]. Journal of Pediatrics of Traditional Chinese Medicine, 2013, 9(2): 10-13 | |
| Authors: | Zhang Jiaquan Wu Liping Meng Luliang |
| Affiliation: | 1.Gansu College of Traditional Chinese Medicine,Lanzhou,Gansu,730000,China; 2.Hospital Affiliated to Gansu College of Traditional Chinese Medicine,Lanzhou,Gansu,730020,China; 3.Medicine College of Shanxi Weinan Vocational and Technical College,Weinan,Shanxi,714000,China) |
| Abstract: | Objective： To explore the situation of learning and memory disorder of Lithium-Pilocarpine induced temporal lobe epilepsy model of rats after spontaneous epilepsy seizures.Methods： Lithium-Pilocarpine induced temporal lobe epilepsy models were established,then Morris water maze and eight arms maze experiment were applied to evaluate the function of learning and memory disorder after spontaneous epilepsy seizures.Results： After spontaneous epilepsy seizures,Morris water maze and eight arms maze experiments appear different obstacle aggravated with the extension of spontaneous epileptic seizure time extension.Conclusion： Lithium-Pilocarpine induced temporal lobe epilepsy shows obvious function disorder of learning and memory after long-term spontaneous epilepsy seizures. |
| Keywords: | Lithium-Pilocarpine temporal lobe epilepsy function of learning and memory rats |
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