| 冠心病患者白细胞膜黏附分子CD11b/CD18表达的研究 |
| |
| 引用本文： | 王雄,刘胜辉,贾永平,窦岩,李运乾. 冠心病患者白细胞膜黏附分子CD11b/CD18表达的研究[J]. 中国循环杂志, 2005, 20(3): 183-185 |
| |
| 作者姓名： | 王雄 刘胜辉 贾永平 窦岩 李运乾 |
| |
| 作者单位： | 1. 030001,山西省,太原市,山西医科大学第一医院心内科
2. 山西医科大学,中心实验室 |
| |
| 摘 要： | 目的探讨冠心病患者中性粒细胞和单核细胞膜黏附分子CD11b/CD1s的表达.方法对60例冠心病患者(冠心病组)采用流式细胞仪直接免疫荧光法与20例正常者(正常组)比较检测中性粒细胞和单核细胞膜黏附分子CD11b/CD18的表达.结果冠心病组中性粒细胞和单核细胞膜黏附分子CD11b/CD18表达较正常组均增加,有显著性差异(P＜0.05),环磷酸腺苷葡胺对不稳定性心绞痛患者干预后,其表达显著增高,有极显著性差异(P＜0.01).结论冠心病患者中性粒细胞和单核细胞膜黏附分子CD1tb/CD18表达明显增加,其增加程度与心肌缺血的类型有关.
|
| 关 键 词： | 冠心病 流式细胞仪 CD11b/CD18 |
| 文章编号： | 1000-3614(2005)03-0183-03 |
| 修稿时间： | 2004-10-02 |
Expression of Adhesion Molecules CD11b/CD18 on Leucocytes in Patients With Coronary Heart Disease |
| |
| Wang Xiong,Liu Shenghui,Jia Yongping,et al.. Expression of Adhesion Molecules CD11b/CD18 on Leucocytes in Patients With Coronary Heart Disease[J]. Chinese Circulation Journal, 2005, 20(3): 183-185 |
| |
| Authors: | Wang Xiong Liu Shenghui Jia Yongping et al. |
| |
| Abstract: | Objective:To investigate the expression of adhesion molecules CD_ 11b/CD_ 18 on neutrophils and monocytes in patients with different type of coronary heart disease (CHD),and to study the effects of meglumine adenosine cyclophosphate on their expression. Methods: The expression of CD_ 11b/CD_ 18 on neutrophils and monocytes were measured by flow cytometry -direct immunofluorescence techniques in 60 patients with CHD . Results: Expressions of CD_ 11b/CD_ 18 on neutrophils and monocytes in the CHD patients were markedly higher than those in normal cases(p<0.05),expressions of CD_ 11b/CD_ 18 markedly increased in patients with unstable angina pectoris in the presence of meglumine adenosine cyclophosphate. Conclusion: Neutrophil and monocyte CD_ 11b/CD_ 18 adhesion molecules in patients with CHD had a higher expression, the degree of increased expression might be related to the types of myocardial ischemia. |
| |
| Keywords: | Coronary heart disease Flow cytometry CD_ 11b/CD_ 18 |
| 本文献已被 CNKI 万方数据 等数据库收录！ |
|
