| TGF-α与IGF-Ⅱ在血液透析中的检测及其临床意义 |
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| 引用本文： | 罗南萍,杨道理,孟建中,徐军,武翠华.TGF-α与IGF-Ⅱ在血液透析中的检测及其临床意义[J].中国免疫学杂志,2000,16(1):49-50. |
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| 作者姓名： | 罗南萍 杨道理 孟建中 徐军 武翠华 |
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| 作者单位： | 1. 济南军区总医院免疫科,济南,250031
2. 济南军区血液净化中心,济南,250031 |
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| 摘 要： | 目的；研究多肽生长因子ＴＧＦ－α与ＩＧＦ－Ⅱ在长期血透（ＨＤ）患者血清及体液中的表达特征。方法；采用放射免疫分析法，检测４５例维持性ＨＤ患者血清１２ｈ尿液中ＴＧＦ－α与ＩＧＦ－Ⅱ的水平。结果：ＴＧＦ－α水平明显低于正常组，ＩＧＦ－Ⅱ则明显高于正常组。ＨＤ后血清中两项指标水平均明显高于ＨＤ前，测定１２ｈ尿液ＴＧＦ－α和ＩＧＦ－Ⅱ含量较正常对照组增高明显。
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| 关 键 词： | 放射免疫分析法 血液透析 TGFα IGF－Ⅱ |
Expression of transforming growth factor-α and insulinlike growth factor in homedialysis patients and its application |
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| LUO Nan-Ping, YANG Dao-Li, MENG Jian- Zheng et al..Expression of transforming growth factor-α and insulinlike growth factor in homedialysis patients and its application[J].Chinese Journal of Immunology,2000,16(1):49-50. |
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| Authors: | LUO Nan-Ping YANG Dao-Li MENG Jian- Zheng |
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| Abstract: | Objective: To study the expression characteristic of TGF-a and IGF-II in maintenance homedialysis patients. Methods:Com-a and IGF-II levels in sera and 12 h urine of 45 maintenance homedialysis patients were detected by radio-immunity analysis. Results: Compared with normal control, serum TGF-a decreased significantly (P < 0.01), and IGF-II increased significantly. Both of TGF-a and IGF-IIlevels in sera and 12 h urine increased significantly after homedialysis (P < 0.05, P < 0.01). Conclusinon: It suggested that the status ofurinaemia and dialyser can stimulate mononuclear cell to synthesis more TGF-a and IGF-II. |
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| Keywords: | Transforming growth factor-a Homedialysis Insulin-like growth factor-II Radio-immunity analysis Dialyser |
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