| 羟考酮临床治疗研究进展 |
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| 引用本文： | 张杜枭,葛卫红,于 锋,谢 菡. 羟考酮临床治疗研究进展[J]. 药学与临床研究, 2014, 22(6): 527-531 |
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| 作者姓名： | 张杜枭 葛卫红 于 锋 谢 菡 |
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| 作者单位： | 1. 南京大学医学院附属鼓楼医院药学部,南京,210008
2. 中国药科大学临床药学教研室,南京,210009 |
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| 摘 要： | 羟考酮（oxycodone）是由蒂巴因（thebaine）改造合成的阿片类中枢神经镇痛药。近几年，随着新的羟考酮剂型的开发，该药物在急性疼痛以及慢性疼痛的控制中均广泛使用，并且出现与少量阿片类药物拮抗剂联用镇痛的方式。本文综述羟考酮的基本药理学性质以及临床应用进展。
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| 关 键 词： | 羟考酮 药理学 临床应用 急性疼痛 慢性疼痛 药物联用 |
| 收稿时间： | 2014-07-01 |
| 修稿时间： | 2014-07-11 |
Development of Oxycodone in Clinical Treatment |
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| ZHANG Du-xiao,GE Wei-hong,YU Feng and XIE han. Development of Oxycodone in Clinical Treatment[J]. Pharmacertical and Clinical Research, 2014, 22(6): 527-531 |
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| Authors: | ZHANG Du-xiao GE Wei-hong YU Feng XIE han |
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| Affiliation: | Department of Pharmacy, Drum Tower Hospital, Nanjing University, Nanjing 210008, China;Department of Pharmacy, Drum Tower Hospital, Nanjing University, Nanjing 210008, China;Department of Clinical Pharmacy, China Pharmaceutical University, Nanjing 210008;Department of Pharmacy, Drum Tower Hospital, Nanjing University, Nanjing 210008, China |
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| Abstract: | Oxycodone is a central nervous system opioid analgesics reformed from thebaine. In recent years, with the development of the formulation of oxycodone, it has been an effective treatment for acute pain and chronic pain. In addition, oxycodone plus opioid receptor antagonist has been developed to improve analgesia in clinical. This article reviews the basic pharmacological properties of oxycodone and its clinical treatment development. |
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| Keywords: | Oxycodone Pharmacology Clinical treatment Acute pain Chronic pain Drug combination |
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