Comparison of the discriminative stimulus properties of delta9-THC and psilocybin in rats. |
| |
Authors: | I Greenberg D Kuhn J B Appel |
| |
Affiliation: | Department of Psychology, University of South Carolina, Columbia, SC, 29208, USA |
| |
Abstract: | Male albino rats were trained to respond differentially on the left or right lever in a 2-lever chamber on the basis of which drug had been given intra-peritoneally (IP) 30 min before experimentation. In 1 group 1.9 mg/kg of delta9-THC and control injections (vehicle) served as the discriminative stimuli associated with each lever and in another group the drug stimuli were 1.0 mg/kg of delta9-THC and 1.0 mg/kg of psilocybin. The results confirmed those of other experiments using different procedures; that delta9-THC can acquire discriminative control over responding. The fact that delta9-THC and psilocybin were also found to differentially control lever choice demonstrates that these 2 drugs probably produce discriminably different states in rats. |
| |
Keywords: | Psilocybin Discrimination State dependent Learning |
本文献已被 ScienceDirect 等数据库收录! |