Role of metabolically active hormones in the insulin resistance associated with short-term glucocorticoid treatment |
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| Authors: | Jeetesh V Patel David E Cummings John P Girod Alwin V Mascarenhas Elizabeth A Hughes Manjula Gupta Gregory YH Lip Sethu Reddy Daniel J Brotman |
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| Affiliation: | (1) Haemostasis Thrombosis and Vascular Biology Unit, University Department of Medicine and Sandwell Medical Research Unit, Sandwell and West Birmingham Hospitals NHS Trust, West Midlands, UK;(2) Department of Medicine, University of Washington, Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA;(3) Department of Cardiology, University of Pittsburgh Medical Center, Pittsburgh, PA, USA;(4) Departments of General Internal Medicine and Endocrinology, Diabetes and Metabolism, Cleveland Clinic Foundation, Cleveland, OH, USA |
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| Abstract: | ![]()
Background The mechanisms by which glucocorticoid therapy promotes obesity and insulin resistance are incompletely characterized. Modulations of the metabolically active hormones, tumour necrosis factor alpha (TNF alpha), ghrelin, leptin and adiponectin are all implicated in the development of these cardiovascular risk factors. Little is known about the effects of short-term glucocorticoid treatment on levels of these hormones. |
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