KRAS 基因突变与结直肠癌转移模式相关性的研究简

目的：研究结直肠癌患者KRAS基因突变与根治后转移的相关性。方法：检测132例结直肠癌根治术患者石蜡组织中的KRAS基因，回顾性分析患者根治术后3年内转移、复发情况，采用单因素及多因素分析KRAS突变与转移的相关性。结果：各转移组KRAS基因突变率分别为：肺（63．2％）、脑（66．7％）、肝（30．4％）及无转移组（34．7％）。单因素分析提示肺、脑转移组KRAS基因突变率显著高于肝转移组及无转移组（P〈0．05）。纳入年龄和性别校正后采用Logistic回归分析提示KRAS突变显著增加肺转移及脑转移风险（P〈0．05），而肝转移风险无显著升高（P〉0．05）。结论：结直肠癌转移模式与KRAS突变有关，检测KRAS突变状态有助于更加有效地制定复发监视策略。

Relationship between mutation of KRAS gene and metastasis pattern in colorectal cancer

Objective：To investigate the relationship between mutation of KRAS gene and metastasis pattern in colorectal cancer. Methods：DNA from 132 surgical specimens taken from patients with eolorectal cancer after curative resection were examined for KRAS gene. Patients＇characteristics and metastasis within 3 years after the surgery were collected retrospectively. Relationship between KRAS mutation and metastasis were analyzed. Results：KRAS mutation rates in each group were：lung metastasis group （63.2%） , brain metastasis group （66.7%）, liver metastasis group （30.4%） and no metastasis group （34.7%）. Single factor analysis suggested KRAS mutation rates in lung metastasis group and brain metastasis group were significantly higher than those in liver metastasis group and non - metastasis group（ P 〈 0.05 ）. After adjusting for age and sex, Logestic regression suggested KRAS mutation was related to higher risk of lung and brain metastasis （ P 〈 0.05 ） , but not with liver metastasis （ P 〉 0.05 ）. Conclusion： KRAS mutation rate is related with metastasis pattern in colorectal cancer, and examination of KRAS mutation may help inform surveillance strategies for patients after curative resection.