NSCLC患者外周血骨桥蛋白检测的意义

目的：探讨外周血骨桥蛋白（OPN）作为非小细胞肺癌患者（NSCLC）肿瘤标志物检测的临床意义。方法：应用酶联免疫吸附试验（ELISA）和放射免疫分析技术（RIA）检测50例NSCLC患者、15例肺部良性病变患者和15例健康正常志愿者外周血OPN和CEA的浓度。结果：NSCLC患者外周血OPN和CEA检测的敏感性分别为7800％和6200％，特异性分别为8667％和9333％，联合检测的敏感性为90.00％。OPN水平与NSCLC的临床分期、淋巴结转移有关，但与组织学分型及远处转移无关。结论：OPN是NSCLC患者的一种较为理想的肿瘤标志物，与CEA联合检测能提高NSCLC诊断的敏感性。

Clinical significance of osteopontin level in peripheral blood of patients with non - small cell lung cancer

Objectlve：To investigate the clinical significance of osteopontin （OPN） as a tumor marker in peripheral blood of patients with non - small cell lung cancer. Methods：Plasma levels of OPN and CEA in 50 eases with non - small cell lung cancers, 15 benign lung diseases and 15 healthy controls were detected by ELISA and RIA methods. Results：The sensitivity of OPN and CEA in patients with cancer was 78.00% and 62.00% , and the specificity of OPN and CEA was 86.67% and 93.33% ,respectively. The sensitivity of coinbined with two inarkers detection was 90.00%. Plamsm levels of OPN were correlated with clinical stage ,lymph node inetastasis, but not correlated with histological type and distant lnetastasis. Conclusion： OPN is a potential tumor lnarker, it eolnbined with CEA can improve the sensitivity of diagnosis in non - small cell lung cancer.