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Chronomics: circadian and circaseptan timing of radiotherapy, drugs, calories, perhaps nutriceuticals and beyond
Authors:Halberg Franz  Cornélissen Germaine  Wang Zhengrong  Wan Chaomin  Ulmer Waldemar  Katinas George  Singh Ranjana  Singh R K  Singh Rajesh Kumar  Gupta B D  Singh R B  Kumar Adarsh  Kanabrocki Eugene  Sothern Robert B  Rao Gundu  Bhatt Madan L B  Srivastava Madhu  Rai Gulshan  Singh Subhash  Pati Atanu Kumar  Nath Panchanan  Halberg Francine  Halberg Julia  Schwartzkopff Othild  Bakken Earl  Governor Shri Vishnu Kant Shastri
Affiliation:University of Minnesota, Minneapolis, MN, USA.
Abstract:
We suggest a putative benefit from timing nutriceuticals (substances that are both nutrients and pharmaceuticals) such as antioxidants for preventive or curative health care, based on the proven merits of timing nutrients, drugs, and other treatments, as documented, i.a., in India. The necessity of timing melatonin, a major antioxidant, is noted. A protocol to extend the scope of chronoradiotherapy awaits testing. Imaging in time by mapping rhythms and broader time structures, chronomes, for earliest diagnoses, for example detection of vascular disease risk, is recommended. The study of rhythms and broader chronomes leads to a dynamic functional genomics, guided by imaging in time of free radicals and antioxidants, amongst many other variables.
Keywords:
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