| 苯磷硫胺对衰老鼠学习记忆能力的影响 |
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| 引用本文： | 费国强,潘晓黎,金莉蓉,钟春玖. 苯磷硫胺对衰老鼠学习记忆能力的影响[J]. 中国临床医学, 2009, 16(5): 683-685 |
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| 作者姓名： | 费国强 潘晓黎 金莉蓉 钟春玖 |
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| 作者单位： | 1. 复旦大学附属中山医院神经内科,上海,200032
2. 上海市杨浦区中心医院神经内科,上海,200090 |
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| 基金项目： | 上海市科委重点基金资助(项目编号:064119536) |
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| 摘 要： | 目的：探讨苯磷硫胺对老年小鼠学习和记忆能力的影响。方法：用Y型迷宫测试衰老鼠后将实验小鼠分成实验组和对照组,分别予添加苯磷硫胺饲料和普通饲料喂养6个月,通过Y迷宫对其学习和记忆能力进行评价,用免疫组化方法观察其海马齿状回颗粒下层细胞的发生情况。结果：实验组小鼠学习记忆能力较对照组明显改善,免疫组化显示BRDU标记的新生细胞数量明显增加。结论：苯磷硫胺能改善正常衰老小鼠学习记忆能力,而海马新生细胞的增加是其作用的可能机理之一。
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| 关 键 词： | 衰老鼠 苯磷硫胺 学习记忆 Y迷宫 免疫组化 |
The Influence for Senile Rats Learning and Memory Ability of Benfotiamine |
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| FEI Guoqiang,PAN Xiaoli,JIN Lirong,ZHONG Chunjiu. The Influence for Senile Rats Learning and Memory Ability of Benfotiamine[J]. Chinese Journal Of Clinical Medicine, 2009, 16(5): 683-685 |
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| Authors: | FEI Guoqiang PAN Xiaoli JIN Lirong ZHONG Chunjiu |
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| Affiliation: | FEI Guoqiang1 PAN Xiaoli2 JIN Lirong1 ZHONG Chunjiu1 1. Department of Neurology,Zhongshan Hospital,Fudan University,Shanghai 200032,China,2. Department of Neurology,Yangpu Center Hospital,Shanghai 200090 |
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| Abstract: | Objective:To study the effect of progress ability for learning and memory of senile rats by benfotiamine. Methods:Dividing senile mice into test and control groups by using Y-maze testing,different feeding diets added benfotiamine and normal diets,evaluating learning and memory by Y-maze,through immunohistochemistry observe the hippocampus dentate gyrus granule cells. Results:Learning and memory ability in test group improved significantly than the control group,the number of BRDU marked newborn cells also ... |
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| Keywords: | Senile Mice Benfotiamine Learning and Memory Y-maze Immunohistochemisty |
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