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Genetic and functional study of the IPO5 gene in schizophrenia |
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| Authors: | Zhen-Qi Wang Yang Liu Ning WuQi Xu Shun-Zi JinGui-Zhi Ju Lin YeLi-bo Liu Xuan Zhang Jiang Wu |
| Affiliation: | a Research Center for Genomic Medicine and MH Radiobiology Research Unit, Jilin University, Changchun 130021, China b Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100005, China c Research Centre for Neuroscience and Department of Neurology, Jilin University First Hospital, Changchun 130021, China |
| Abstract: | The present work reported on a weak association of the importin 5 (IPO5) gene with schizophrenia in combined family and case-control samples and also investigated a possible mechanism by which the IPO5 gene may contribute to the development of the disease in a Chinese population. Our results suggest that abnormal expression and alternative splicing of the IPO5 gene may be involved in the pathophysiology of schizophrenia. |
| Keywords: | Association analysis Functional study IPO5 Schizophrenia |
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