间充质干细胞来源胞外囊泡救治辐射损伤的研究进展

间充质干细胞来源胞外囊泡（MSC-EV）在保留间充质干细胞（MSC）生物学功能的同时，能够避免MSC内在缺陷；MSC-EV脂质双分子层结构能够避免其脂质、蛋白、DNA、RNA等内容物被酶类物质降解；此外，MSC-EV适合通过永生化MSC技术进行大规模制备。因此，与MSC相比，MSC-EV是一种新型高效、安全、便捷、可行的非细胞治疗方法，且在组织修复及免疫调节方面呈现出同等功效。本文仅就MSC-EV在辐射损伤救治方面的研究进展作一综述。

Role of mesenchymal stem cell derived extracellular vesicles in radiation injuries

Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) conserve MSC' bioactivity, while overcome certain safety concerns related to MSC. The phospholipid bilayer of MSC-EVs may protect their contents, such as lipid, protein, DNA, RNA, from degradation by circulatory enzymes. Moreover, large scale MSC-EVs could be obtained through immortalized MSC technique. Thus, MSC-EVs based therapy is a more efficient, convenient, feasible, safer cell free therapy strategy compared with MSC. So far, MSC-EVs present similar function to MSC in the field of regenerative medicine and immunomodulation. Herein, the recent research progress about the role and the involved mechanisms of MSC-EVs in radiation injuries are systematically reviewed.